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经验配方 CAS号 C₁₅H₁₀N₂O₂ 91300-60-6 描述 概述 A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50 = 2 µM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. 产品目录编号 440205 品牌系列 Calbiochem®
同义词 6-Anilino-5,8-quinolinequinone 参考 参考 Adachi, R., et al. 2000. Int. J. Immunopharmacol. 22, 855.
Kawada, T., et al. 1994. Gen. Pharmacol. 25, 1361.
Beasley, D., et al. 1991. J. Clin. Invest. 87, 602.
Pandol, S.J., et al. 1990. J. Biol. Chem. 265, 12846.
Light, D.B., et al. 1989. Science 243, 383.
Mulsch, A. 1988. J. Pharmacol. Exp. Ther. 247, 283.
Fleisch, J.H., et al. 1984. J. Pharmacol. Exp. Ther. 229, 681.产品信息 CAS号 91300-60-6 具有ATP竞争性 N 形式 Reddish purple solid Hill配方 C₁₅H₁₀N₂O₂ 化学配方 C₁₅H₁₀N₂O₂ Molar Mass 250.2 可逆 N 结构配方图像 生物信息 主靶 soluble guanylate cyclase 主靶IC50 2 µM against soluble guanylate cyclase 纯度 ≥98% by TLC and HPLC 理化信息 细胞可渗透 Y 溶解度 EtOH 安全信息 R相 R: 22-36/37/38-45-46-48
Harmful if swallowed.
Irritating to eyes, respiratory system and skin.
May cause cancer.
May cause heritable genetic damage.
Danger of serious damage to health by prolonged exposure.S相 S: 22-26-36/37/39-45
Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful & Carcinogenic / Teratogenic
储存 +2°C to +8°C
无需冷冻 No
特殊指南 Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C or up to 6 months at -20°C.
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