merck millipore,默克密理愽
  • merck millipore,默克密理博,554726,REV-ERB Agonist II, SR9009 - Calbiochem

  • merck millipore,默克密理博,554726,REV-ERB Agonist II, SR9009 - Calbiochem

    产品名称：REV-ERB Agonist II, SR9009 - Calbiochem
    产品型号：554726
    The REV-ERB Agonist II, SR9009 controls the biological activity of REV-ERB. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,554726,REV-ERB Agonist II, SR9009 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,554726,REV-ERB Agonist II, SR9009 - Calbiochem

    重要规格表

    经验配方
    C₂₀H₂₄ClN₃O₄S
    描述
    概述 A pyrrolidinecarbamate compound that acts as a specific REV-ERB-α/β agonist. Exhibits a direct and reversible binding (Kd = 800 nM REV-ERB-α) and shows excellent selectivity over a panel of 46 other nuclear receptors. Potently increases REV-ERB-dependent repressor activity (IC50 = 670 and 800 nM in Gal4-REV-ERB-α and β transfected HEK 293 cells) and reduces BMAL1 mRNA in HepG2 cells (IC50 = 710 nM). Shown to cross the blood-brain barrier and exhibit desirable pharmacokinetic properties. A 7-day administration of SR9009 (100 mg/kg, i.p., b.i.d.) causes a significant weight and fat loss in C57BL6 mice with concomitant reduction in plasma glucose and free fatty acid levels, and alters circadian pattern.
    产品目录编号 554726
    品牌系列 Calbiochem®
    同义词 Ethyl-3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate
    参考
    参考 Solt, L.A., et al. 2012. Nature 485, 62.
    产品信息
    形式 Dark brown liquid
    Hill配方 C₂₀H₂₄ClN₃O₄S
    Molar Mass 437.9
    可逆 Y
    结构配方图像
    生物信息
    主靶 REV-ERB-α/&beta
    纯度 ≥96% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,554726,REV-ERB Agonist II, SR9009 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,SF-736,MYC; Human, Cyanine 3, RNA Detection Probe,SmartFlare


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