merck millipore,默克密理博,04-721,Anti-Dicer1 Antibody, clone 5D12.2

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	M	Purified	Monoclonal Antibody

描述
产品目录编号	04-721
品牌系列	Upstate
商名	Upstate
描述	Anti-Dicer1 Antibody, clone 5D12.2
Alternate Names	KIAA0928 DCR1 Dicer HERNA
背景信息	RNA interference (RNAi) is mechanism for post-transcriptional gene silencing that leads to the loss of the activity of the gene. RNAi is activated when long dsRNAs are cleaved by the enzyme Dicer1 (RNase III family of dsRNA-specific endonucleases) into 21-23 nucleotide siRNA (small interfering RNA). These siRNAs bind proteins to form the RISC (RNA-induced silencing complex) which is activated when the double stranded siRNAs are unzipped to single stranded siRNAs. Activated RISC recognizes and binds complementary sequences in mRNA. The mRNA is cleaved and the overall effect is an inhibition of the protein expression and a loss of the gene activity. Dicer1 along with the Argonaute family of proteins (Ago1 and Ago2) share the same domain PIWI and PAZ domain that provide endonuclease activity to RNA-induced silencing complexes (RISC).

产品信息
格式	Purified

应用
应用	Anti-Dicer1 Antibody, clone 5D12.2 is a Mouse Monoclonal Antibody for detection of Dicer1 also known as DCR1, Dicer, HERNA, KIAA0928 & has been validated in WB.
主要应用	Western Blotting
应用说明	Western blot

生物信息
免疫原品种	KLH conjugated synthetic peptide corresponding to amino acids 378-385 of human Dicer1
克隆	5D12.2
宿主	Mouse
特异性	Human Dicer1
同种型	IgG1κ
品种反应性	Human
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_085124.2
基因符号	HERNA DICER1 DICER
纯化方法	Protein G chromatography
UniProt编号	Q9UPY3

产品使用声明
质量保证	Routinely evaluated by western blot on lysates from HeLa nuclear extracts.

储存和货运信息
存储条件	Maintain at 2-8°C in undiluted aliquots for up to 6 months after date of receipt.

包装信息
数量	100 µL

merck millipore,默克密理博,04-721,Anti-Dicer1 Antibody, clone 5D12.2

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