merck millipore,默克密理愽
  • merck millipore,默克密理博,553030,RAGE Antagonist, FPS-ZM1 - Calbiochem

  • merck millipore,默克密理博,553030,RAGE Antagonist, FPS-ZM1 - Calbiochem

    产品名称：RAGE Antagonist, FPS-ZM1 - Calbiochem
    产品型号：553030
    The RAGE Antagonist, FPS-ZM1 controls the biological activity of RAGE. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,553030,RAGE Antagonist, FPS-ZM1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553030,RAGE Antagonist, FPS-ZM1 - Calbiochem

    重要规格表

    经验配方
    C₂₀H₂₂ClNO
    描述
    概述 A blood-brain-barrier-permeant, non-toxic, tertiary amide compound that acts as a high affinity, potent, multimodal blocker of RAGE (Receptor for Advanced Glycation End products) V domain-mediated ligand binding (Ki = 25, 148, and 230 nM, respectively, against Aβ40, HMGB1, and S100B, binding to sRAGE). Blocks RAGE-mediated influx of Aβ40 and Aβ42 into the brain. Also shown to suppress Aβ-RAGE induced NF-κB activation and NF-κB-dependent transcription of β-secretase. Daily treatment of APPsw/0 murine AD model (1 mg/kg/d via i.p.) is reported to greatly reduce Thioflavin S-positive amyloid plaques in cortex and hippocampus (by 70 to 80%) and restore congnitive performance to the level of non-AD mice.
    产品目录编号 553030
    品牌系列 Calbiochem®
    同义词 Receptor for AGE Antagonist, FPS-ZM1, N-Benzyl-4-chloro-N-cyclohexylbenzamide
    参考
    参考 Deane, R., et al. 2012. J. Clin. Invest. 122, 1377.
    产品信息
    形式 Yellowish-white solid
    Hill配方 C₂₀H₂₂ClNO
    Molar Mass 327.9
    可逆 Y
    结构配方图像
    生物信息
    主靶 RAGE
    主靶Ki 25, 148, and 230 nM, respectively, against A&beta
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553030,RAGE Antagonist, FPS-ZM1 - Calbiochem

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