merck millipore,默克密理愽
  • merck millipore,默克密理博,553016,Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem

  • merck millipore,默克密理博,553016,Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem

    产品名称：Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem
    产品型号：553016
    The Raf Kinase Inhibitor VI, also referenced under CAS 331444-40-7, controls the biological activity of Raf Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylat More>>

    merck millipore,默克密理博,553016,Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,553016,Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₂N₄O₃S331444-40-7
    描述
    概述 A purine-2,6-dione compound that targets the ATP-binding pocket of B-Raf and effectively inhibits the phosphorylation of MEK by wild-type B-Raf in cell-free in vitro kinase assays (IC50 = 1.7 µM and Ki, app = 106 nM with 100 µM ATP). Reported to be equally potent against the oncogenic V600E B-Raf mutant and exhibit much less activity against PI 3-Kγ (IC50 = 25 µM) and more than 50-fold selectivity over PAK1, GSK-3β, PAK4, MST1, and PIM1 (IC50 ≥ 100 µM).
    产品目录编号 553016
    品牌系列 Calbiochem®
    同义词 1,7-Dibenzyl-8-(2-hydroxyethylsulfanyl)-3-methyl-purine-2,6-dione
    参考
    参考 Luo, C., et al. 2008. J. Med. Chem. 51, 6121.
    产品信息
    CAS号 331444-40-7
    形式 White solid
    Hill配方 C₂₂H₂₂N₄O₃S
    化学配方 C₂₂H₂₂N₄O₃S
    Molar Mass 422.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,553016,Raf Kinase Inhibitor VI - CAS 331444-40-7 - Calbiochem

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