merck millipore,默克密理愽
  • merck millipore,默克密理博,550601,Pyruvate Kinase Activator - Calbiochem

  • merck millipore,默克密理博,550601,Pyruvate Kinase Activator - Calbiochem

    产品名称：Pyruvate Kinase Activator - Calbiochem
    产品型号：550601
    The Pyruvate Kinase Activator controls the biological activity of Pyruvate Kinase. This small molecule/inhibitor is primarily used for Activators/Inducers applications.

    merck millipore,默克密理博,550601,Pyruvate Kinase Activator - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,550601,Pyruvate Kinase Activator - Calbiochem

    重要规格表

    经验配方
    C₁₅H₁₁ClF₂N₂O₃S
    描述
    概述 A cell-permeable and biologically stable (t1/2 = 277.2 and 117.5 min., respectively, in human and mouse liver microsome preparation) tetrahydroquinoline-sulfonamide that enhances the donor PEP, but not the acceptor ADP, substrate affinity toward pyruvate kinase isoform PKM2 (Km = 0.4 vs. 1.9 mM with or without 10 µM activator) and acts as a potent PKM2-selective activator (AC50 = 90 nM using rhPKM2; ACmax = 88%), displaying much reduced activity toward PKL (≤25% at 57 µM) and no effect toward PKM1 or PKR.
    产品目录编号 550601
    品牌系列 Calbiochem®
    同义词 N-(4-Chloro-3-fluorophenyl)-7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide, PKM2 Activator I
    参考
    参考 Walsh, M.J., et al. 2011. Bioorg. Med. Chem. Lett. 21, 6322.
    产品信息
    形式 White powder
    Hill配方 C₁₅H₁₁ClF₂N₂O₃S
    化学配方 C₁₅H₁₁ClF₂N₂O₃S
    Molar Mass 372.8
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,550601,Pyruvate Kinase Activator - Calbiochem

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