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merck millipore,默克密理博,529685,Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem
产品名称：Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem
产品型号：529685
A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance.
merck millipore,默克密理博,529685,Prodigiosin Serratia marcescens - CAS 82-89-3 - Calbiochem
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重要规格表
经验配方 CAS号 C₂₀H₂₅N₃O 82-89-3 描述 概述 A cell-permeable tripyrrole alkaloid compound that displays immunosuppressive and anti-tumor properties irrespective of p53 status and multidrug resistance. Shown to selectively upregulate p21WAF/CIP1 and NAG-1 (nonsteroidal anti-inflammatory drug-activated gene 1) and downregulate survivin expression levels, induce mitochondria-mediated apoptosis and cell cycle arrest in tumor cells. Prevents FADD phosphorylation (IC50 = 2.0 µM in A549-FKR cells) through inhibition of FADD-kinase CK1α (IC50 ~ 6.0 µM in SW620-BGCR cells) and augments cisplatin (Cat. No. 232120)-induced apoptosis. Blocks NF-κB activation by decreasing pIκBα (by 63% at 3 µM) and IκBα levels in A549 cells, and shrinks tumor growth in A549-FKR tumor xenograft mouse model (3 mg/kg, i.p., o.d.). 产品目录编号 529685 品牌系列 Calbiochem®
同义词 Casein Kinase I Inhibitor IV, 2-Methyl-3-pentyl-6-methoxyprodigiosene, NSC 47147 参考 参考 Schinske, K.A., et al. 2011. Mol. Cancer Ther. 10, 1807.
Chang, C.C., et al. 2011. J. Biosci. Bioeng. 5, 501
Ho, T.F., et al. 2009. Toxicol. Appl. Pharmacol. 235, 253
Soto-Cerrato, V., et al. 2007.Mol. Cancer Ther. 6, 362.产品信息 CAS号 82-89-3 形式 Dark red solid Hill配方 C₂₀H₂₅N₃O 化学配方 C₂₀H₂₅N₃O Molar Mass 323.4 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO, DMF, EtOH, MeOH 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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