merck millipore,默克密理愽
  • merck millipore,默克密理博,516571,PPAR Agonist IX, GQ-16 - Calbiochem

  • merck millipore,默克密理博,516571,PPAR Agonist IX, GQ-16 - Calbiochem

    产品名称：PPAR Agonist IX, GQ-16 - Calbiochem
    产品型号：516571
    The PPAR Agonist IX, GQ-16 controls the biological activity of PPAR. This small molecule/inhibitor is primarily used for Biochemicals applications.

    merck millipore,默克密理博,516571,PPAR Agonist IX, GQ-16 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,516571,PPAR Agonist IX, GQ-16 - Calbiochem

    重要规格表

    经验配方
    C₁₉H₁₆BrNO₃S
    描述
    概述 A cell-permeable thiazolidinedione that acts as a PPARγ-selective agonist (Ki = 160 nM) and blocks Cdk-5-mediated Ser273 phosphorylation by stabilizing PPARγ β-sheet structure, exhibiting no detectable activity towards PPARα, PPARδ, or RXRα. Although a weaker PPAPγ agonist than Thiazolidinediones (TZDs) family rosiglitazone (Cat. No. 557366; Max. fold of transactivation induction = 8.57 and 24.8 with 10 µM respective compound in U-937 reporter assays), GQ-16 can be safely administered at a higher dosage (20 mg/kg/day; oral gavage) in mice to achieve similar in vivo efficacy as rosiglitazone (4 mg/kg/day; o.g.) without adverse side effects commonly seen with TZDs.
    产品目录编号 516571
    品牌系列 Calbiochem®
    同义词 (Z)-5-(5-Bromo-2-methoxybenzylidene)-3-(4-methyl-benzyl)-thiazolidine-2,4-dione
    参考
    参考 Amato, A.A., et al. 2012. J. Biol. Chem. 287, 28169.
    产品信息
    形式 Pale yellow solid
    Hill配方 C₁₉H₁₆BrNO₃S
    Molar Mass 418.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 PPARγ
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,516571,PPAR Agonist IX, GQ-16 - Calbiochem

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