merck millipore,默克密理博,203709,Insulin Expression Inducer, BRD7389 - CAS 376382-11-5

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Merck Millipore 默克密理愽

merck millipore,默克密理博,203709,Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem

经验配方	CAS号
C₂₄H₁₈N₂O₂	376382-11-5

描述
概述	A cell-permeable naphthoquinolinedione compound that is reported to preferentially inhibit 23 kinases (IC₅₀ ≤10 µM) from a panel of 219, notably IRR (h), CLK2(h), Rsk1(h), Flt3(h), Rsk1(r), Rsk2(h), Haspin(h), Rsk4(h), Melk(h), Drak1(h), Rsk3(h), and CK13(h) (% inhibition by 10 µM BRD7389 = 91, 87, 86, 79, 78, 76, 74, 73, 73, 72, 71, and 71, respectively). Shown to induce β-cell-like morphology in cultured murine pancreatic α-cell αTC1 and stimulate the expression of insulin mRNA (by ~50-fold; 0.85 µM for 5 d) and protein (by 1.5-fold; 3.4 µM for 5 d), as well as other β-cell mRNAs, including Iapp, Npy, Pdx1, and Pax4, in αTC1 cultures. In human primary islets cultures, BRD7389 treatments result in a decrease of overall cell counts over time due to apoptosis induction, while insulin-positive population, and in some cases also glucagon-positive cell population, remains more or less unaffected.
产品目录编号	203709
品牌系列	Calbiochem®
同义词	1-((2-Phenylethyl)amino)-3H-naphtho[1,2,3-de]quinoline-2,7-dione, Insulin Receptor-Related Protein Inhibitor, IRR Inhibitor, INSRR Inhibitor, RSK Inhibitor III

参考
参考	Fomina-Yadlin, D., et al. 2010. Proc. Natl. Acad. Sci. USA 107, 15099.

生物信息
纯度	≥98% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性	Regulatory Review
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following recontitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,203709,Insulin Expression Inducer, BRD7389 - CAS 376382-11-5 - Calbiochem

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