merck millipore,默克密理愽
  • merck millipore,默克密理博,516568,PPARβ/δ Inverse Agonist - Calbiochem

  • merck millipore,默克密理博,516568,PPARβ/δ Inverse Agonist - Calbiochem

    产品名称：PPARβ/δ Inverse Agonist - Calbiochem
    产品型号：516568
    The PPARβ/δ Inverse Agonist controls the biological activity of PPARβ/δ.

    merck millipore,默克密理博,516568,PPARβ/δ Inverse Agonist - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,516568,PPARβ/δ Inverse Agonist - Calbiochem

    重要规格表

    经验配方
    C₁₉H₂₆N₂O₅S₂
    描述
    概述 A cell-permeable, diaryl sulfonamide inverse agonist that demonstrates selectivity for the ligand-binding domain of the PPAR β/δ receptor (IC50 = 93 nM). Enhances the interaction of the PPARβ/δ ligand-binding domain with the co-repressor, SMRT-ID2 (EC50 = 10 nM). Down-regulates the peroxisome proliferator response elements (PPREs)-driven target gene, ANGPTL4. Inhibits PPARβ/δ- specific agonist-induced transcriptional activity in human myofibroblasts and mouse thioglycollate-elicited peritoneal macrophages.
    产品目录编号 516568
    品牌系列 Calbiochem®
    同义词 methyl 3-(N-(4-(hexylamino)-2-methoxyphenyl)sulfamoyl)thiophene-2-carboxylate (ST247)
    参考
    参考 Naruhn, S., et al. 2011., Mol Pharmacol. 80, 828.
    产品信息
    形式 Yellow solid
    Hill配方 C₁₉H₂₆N₂O₅S₂
    化学配方 C₁₉H₂₆N₂O₅S₂
    Molar Mass 426.55
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,516568,PPARβ/δ Inverse Agonist - Calbiochem

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