- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
-
-
merck millipore,默克密理博,513035,PD 158780 - CAS 171179-06-9 - Calbiochem
产品名称：PD 158780 - CAS 171179-06-9 - Calbiochem
产品型号：513035
A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC₅₀ = 8 pM).
merck millipore,默克密理博,513035,PD 158780 - CAS 171179-06-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₄H₁₂BrN₅ 171179-06-9 描述 概述 A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC50 = 8 pM). Also inhibits heregulin-stimulated autophosphorylation in SK-BR-3 (IC50 = 49 nM) and MDA-MB-453 (IC50 = 52 nM) breast carcinomas. The inhibition is competitive and results from binding of the inhibitor at the ATP site of the enzymes. Inhibits the LPA-stimulated MAP kinase kinase 1/2 (MKK1/2) activation and EGFR tyrosine phosphorylation in HeLa and NIH 3T3 cells. A 10 mM (500 µg/151 µl) solution of PD 158780 (Cat. No. 513036) in DMSO is also available. 产品目录编号 513035 品牌系列 Calbiochem®
同义词 4-[(3-Bromophenyl)amino]-6-(methylamino)-pyrido[3,4-d]pyridimine 参考 参考 Cunnick, J.M., et al. 1998. J. Biol. Chem. 273, 14468.
Rewcastle, G.W., et al. 1998. J. Med. Chem. 41, 742.产品信息 CAS号 171179-06-9 具有ATP竞争性 Y 形式 Yellow solid Hill配方 C₁₄H₁₂BrN₅ 化学配方 C₁₄H₁₂BrN₅ Molar Mass 330.2 可逆 Y 结构配方图像 生物信息 主靶 EGFR tyrosine kinase 主靶IC50 8 pM against EGFR tyrosine kinase activity; 49 nM, 52 nm, against heregulin-stimulated autophosphorylation in SK-BR-3 and MDA-MB-453 breast carcinomas, respectively 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,64245,L-3,3ʹ,5-Triiodothyronine, Sodium Salt - CAS 55-06-1 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,360512,Glycocholic Acid, Sodium Salt - CAS 863-57-0 - Calbiochem
相关产品
merck millipore,默克密理博,AB3209,Anti-Oct-4 Antibody
merck millipore,默克密理博,14-741M,CHK2 (I157T), active
merck millipore,默克密理博,580217,Taurocholic Acid, Sodium Salt - CAS 145-42-6 - Calbiochem
merck millipore,默克密理博,64245,L-3,3ʹ,5-Triiodothyronine, Sodium Salt - CAS 55-06-1 - Calbiochem
merck millipore,默克密理博,360512,Glycocholic Acid, Sodium Salt - CAS 863-57-0 - Calbiochem
merck millipore,默克密理博,566330,SIRT1/2 Inhibitor VIII, Salermide - CAS 1105698-15-4 - Calbiochem
merck millipore,默克密理博,ABN481,Anti-Synaptopodin Antibody
merck millipore,默克密理博,SF-1942,BAP1; Human, Cyanine 5 RNA Detection Probe,SmartFlare
