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merck millipore,默克密理博,506164,mutant p53 Reactivator, RETRA - CAS 1036069-26-7 - Calbiochem
产品名称：mutant p53 Reactivator, RETRA - CAS 1036069-26-7 - Calbiochem
产品型号：506164
The mutant p53 Reactivator, RETRA, also referenced under CAS 1036069-26-7, controls the biological activity of mutant p53. This small molecule/inhibitor is primarily used for Activators/Inducers appli More>>
merck millipore,默克密理博,506164,mutant p53 Reactivator, RETRA - CAS 1036069-26-7 - Calbiochem
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重要规格表
经验配方 CAS号 C₁₁H₁₁NO₃S₂ • HCl 1036069-26-7 描述 概述 A cell-permeable thioethanone compound that upregulates p53 family-responsive element-dependent reporter plasmid transcription activity in cells bearing Glu266, His273, Lys280, or Trp278 mutant p53 by increasing the cellular protein, but not mRNA, level of the p53 homologue p73 (by ~3.7-fold in A431 cells in 20 h with 2 µg/ml RETRA) as well as by disrupting p73 interaction with mutant p53, while exhibiting no similar effects in wild-type p53-bearing or p53-null cells. RETRA is shown to increase transcription of proapoptotic genes (5- and >10-fold increase, respectively, of PUMA/BBC3 and p21/CDKN1A, with 1.5 µg/ml RETRA for 14 h), induce apoptosis, and inhibit the growth of A431, but not wild-type p53-bearing or p53-null cells, in a p53- and p73-dependent manner in vitro, as well as delay (by ~4 days) and reduce (by ~50% on day 25) A431-derived tumor formation in mice (0.4 mg/animal via 6 daily i.p.) in vivo. 产品目录编号 506164 品牌系列 Calbiochem®
同义词 p53 Activator VI, p73 Activator, 2-(4,5-Dihydro-1,3-thiazol-2-ylthio)-1-(3,4-dihydroxyphenyl)ethanone, HCl, Reactivation of Transcriptional Reporter Activity 参考 参考 Kravchenko, J.E., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 6302. 产品信息 CAS号 1036069-26-7 形式 Off-white solid Hill配方 C₁₁H₁₁NO₃S₂ • HCl 化学配方 C₁₁H₁₁NO₃S₂ • HCl Molar Mass 305.8 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 25
Toxic if swallowed.S相 S: 24/25-36/37/39-45
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Toxic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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