merck millipore,默克密理博,506132,Pifithrin-α - CAS 63208-82-2

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,506132,Pifithrin-α - CAS 63208-82-2 - Calbiochem
产品名称：Pifithrin-α - CAS 63208-82-2 - Calbiochem
产品型号：506132
A cell-permeable chemical inhibitor of p53.

merck millipore,默克密理博,506132,Pifithrin-α - CAS 63208-82-2 - Calbiochem

产品介绍

merck millipore,默克密理博,506132,Pifithrin-α - CAS 63208-82-2 - Calbiochem

重要规格表

经验配方	CAS号
C₁₆H₁₈N₂OS·HBr	63208-82-2

描述
概述	A cell-permeable chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. Inhibits p53-dependent growth arrest of human diploid fibroblasts in response to DNA damage but has no effect on p53-deficient fibroblasts. Protects normal tissues from the deleterious side effects of chemotherapy. Has been reported to protect neurons against β-amyloid peptide and glutamate-induced apoptosis.
产品目录编号	506132
品牌系列	Calbiochem®
同义词	2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone, HBr

参考
参考	Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195. Culmsee, C., et al. 2001. J. Neurochem. 77, 220. Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41. Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98. Ferber, D. 1999. Science 285, 1651. Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894. Komarov, P.G., et al. 1999. Science 285, 1733.

参考

Murphy, P.J.M., et al. 2004. J. Biol. Chem. 279, 30195.
Culmsee, C., et al. 2001. J. Neurochem. 77, 220.
Komarova, E.A., and Gudkov, A.V. 2000. Biochemistry (Mosc.) 65, 41.
Stadler, P., et al. 2000. Strahlenther Onkol. 176, 98.
Ferber, D. 1999. Science 285, 1651.
Jacquemin-Sablon, A. 1999. Bull. Cancer 86, 894.
Komarov, P.G., et al. 1999. Science 285, 1733.

产品信息
CAS号	63208-82-2
具有ATP竞争性	N
形式	Off-white solid
Hill配方	C₁₆H₁₈N₂OS·HBr
化学配方	C₁₆H₁₈N₂OS·HBr
Molar Mass	367.3
可逆	Y
结构配方图像

生物信息
主靶	PS3
纯度	≥95% by HPLC

理化信息
细胞可渗透	Y
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot into cold tubes and freeze (-20°C). Stock solutions in DMSO are stable for 3 months at -20°C. Unstable in aqueous solutions.