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merck millipore,默克密理博,506106,p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
产品名称：p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
产品型号：506106
The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This small molecule/inhibitor is primarily used for Phosp More>>
merck millipore,默克密理博,506106,p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,506106,p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem
重要规格表
经验配方 CAS号 C₂₀H₁₄O₂S₂ 42521-82-4 描述 概述 A cell-permeable symmetrical disulfide allosteric inhibitor that selectively targets the autoregulatory domain of group I, but not group II, PAKs (p21-activated kinases) and prevents the activation of PAK1/2/3 (% inhibition= 95, 70, and 60, respectively, with 10 µM inhibitor; IC50 = 2.5 µM for PAK1). Specificity test shows ≥ 50% inhibition, in the presence of 10 µM ATP and inhibitor, against 9 of 214 non-PAK human kinases. Shown to effectively suppress both basal and PDGF-induced PAK activation at 30 µM in mouse embryonic fibroblasts. IPA-3 does not inhibit the enzymatic activity of preactivated PAKs and reduction of the intramolecular disulfide bond of IPA-3 by DTT renders it inactive. 产品目录编号 506106 品牌系列 Calbiochem®
同义词 2,2ʹ-Dihydroxy-1,1ʹ-dinaphthyldisulfide, PAK Inhibitor III 参考 参考 Deacon, S.W., et al. 2008. Chem. Biol. 15, 322. 产品信息 CAS号 42521-82-4 形式 Yellow solid Hill配方 C₂₀H₁₄O₂S₂ 化学配方 C₂₀H₁₄O₂S₂ Molar Mass 350.5 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO or EtOH 安全信息 R相 R: 36/37/38
Irritating to eyes, respiratory system and skin.S相 S: 26-36-45
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Irritant
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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下一件merck millipore产品：merck millipore,默克密理博,189405,Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem
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