merck millipore,默克密理愽
  • merck millipore,默克密理博,499610,(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

  • merck millipore,默克密理博,499610,(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

    产品名称：(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem
    产品型号：499610
    A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity in an ATP-competitive and irreversible manner.

    merck millipore,默克密理博,499610,(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,499610,(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₂₂O₇66018-38-0
    描述
    概述 A naturally isolated cell-permeable fungal resorcylic lactone that acts as a selective and highly potent inhibitor against the MAPKKK TAK1 activity (IC50 = 8 nM) in an ATP-competitive and irreversible manner, while inhibiting MEK1 (IC50 = 411 nM) and three other MAPKKKs (IC50 ≥268 nM against MEKK1, ASK1, and MEKK4) only at much higher concentrations. Shown to inhibit IL-1-induced/TAK1-mediated, but not H2O2-induced/TAK1-independent, JNK and p38 phosphorylation in 293 cells. (5Z)-Zeaenol, Curvularia sp. (Cat. No. 499609) may serve as a negative control.
    产品目录编号 499610
    品牌系列 Calbiochem®
    同义词 TAK1 Inhibitor
    参考
    参考 Windheim, M., et al. 2007. Biochem. J. 404, 179.
    Choo, M.K., et al. 2006. Mol. Cancer Ther. 5, 2970.
    Safwat, N., et al. 2005. Endocrinology 146, 4814.
    Ninomiya-Tsuji, J., et al. 2003. J. Biol. Chem. 278, 18485.
    Rawlins, P., et al. 1999. Int. J. Immunopharmacol. 21, 799.
    产品信息
    CAS号 66018-38-0
    形式 White solid
    Hill配方 C₁₉H₂₂O₇
    化学配方 C₁₉H₂₂O₇
    Molar Mass 362.4
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    安全信息
    S相 S: 22-24/25-36/37/39

    Do not breathe dust.
    Avoid contact with skin and eyes.
    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,499610,(5Z)-7-Oxozeaenol, Curvularia sp. - CAS 66018-38-0 - Calbiochem

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下一件merck millipore产品：merck millipore,默克密理博,MABC76,Anti-Stabilin-2 Antibody, clone mAb-174


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