merck millipore,默克密理愽
  • merck millipore,默克密理博,481406,NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

  • merck millipore,默克密理博,481406,NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

    产品名称：NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem
    产品型号：481406
    The NF-κB Activation Inhibitor, also referenced under CAS 545380-34-5, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applicatio More>>

    merck millipore,默克密理博,481406,NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,481406,NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₂H₂₀N₄O545380-34-5
    描述
    概述 A cell-permeable quinazoline compound that acts as a highly potent inhibitor of NF-κB transcriptional activation (IC50 = 11 nM in Jurkat cells) and LPS-induced TNF-α production (IC50 = 7 nM in murine splenocytes). Shown to exhibit anti-inflammatory effect on carrageenin-induced paw edema in rat. A 10 mM (1 mg/281 µl) solution of NF-κB Activation Inhibitor (Cat. No. 481407) in DMSO is also available.
    产品目录编号 481406
    品牌系列 Calbiochem®
    同义词 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline
    参考
    参考 Tobe, M., et al. 2003. Bioorg. Med. Chem. 11, 383.
    产品信息
    CAS号 545380-34-5
    具有ATP竞争性 N
    形式 Off-white solid
    Hill配方 C₂₂H₂₀N₄O
    化学配方 C₂₂H₂₀N₄O
    Molar Mass 356.4
    可逆 N
    结构配方图像
    生物信息
    主靶 NF-κB transcriptional activation
    主靶IC50 11 nM against NF-κB transcriptional activation in Jurkat cells
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Toxic
    有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,481406,NF-κB Activation Inhibitor - CAS 545380-34-5 - Calbiochem

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