merck millipore,默克密理愽
  • merck millipore,默克密理博,480026,NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

  • merck millipore,默克密理博,480026,NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

    产品名称：NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem
    产品型号：480026
    A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC₅₀ More>>

    merck millipore,默克密理博,480026,NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,480026,NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

    重要规格表

    经验配方
    C₁₂₃H₁₉₇N₄₇O₃₂
    描述
    概述 A cell-permeable cytoplasmic transduction peptide (CTP; YGRRARRRARR) fused to the NEMO binding domain peptide (NBD; TALDWSWLQTE) that acts as a potent inhibitor of TNFα-stimulated NF-κB activity (IC50 ~ 50 µM in HCT116 cells). Acts by interfering with the formation of active IKK complex and thereby prevents IκBα phosphorylation and its subsequent proteasomal degradation. Also blocks LPS-mediated increase in inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) activities. Colon-targeted capsules containing CTP-NBD are shown to reduce 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis in rodent models (4.5 mg/kg/,p.o.) in vivo and diminish activities of myeloperoxidase and several inflammatory mediators. Antennapedia fused NBD cell-permeable peptide is also available (Cat. No. 480025).
    产品目录编号 480026
    品牌系列 Calbiochem®
    同义词 NEMO-Binding Domain Binding Peptide II, Cell-Permeable, CTP-NBD
    参考
    参考 Hong, S., et al. 2012. Mol. Pharm. 9, 1310.
    Kim, D., et al. 2006. Exp. Cell Res. 312, 1277.
    产品信息
    形式 White solid
    配方 Supplied as a trifluoroacetate salt.
    Hill配方 C₁₂₃H₁₉₇N₄₇O₃₂
    Molar Mass 2846.2
    吸湿 Hygroscopic
    肽序列 Ac-YGRRARRRARRTALDWSWLQTE-NH₂
    可逆 Y
    基于肽含量售出 Yes
    生物信息
    主靶 NEMO-binding peptide
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 H₂O
    肽含量 Yes
    肽序列 Ac-YGRRARRRARRTALDWSWLQTE-NH₂
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,480026,NBD-Binding Peptide II, Cell Permeable, CTP-NBD - Calbiochem

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