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经验配方 CAS号 C₁₅H₁₀O₈ 529-44-2 描述 概述 A cell-permeable flavanoid that displays anti-inflammatory, anti-diabetic and anti-cancer properties. Acts as a non-ATP competitive MEK1 inhibitor (IC50 < 3 µM), and ATP-competitive inhibitors of CKI, CKII, IR, MLCK, PKA and PKC (Ki = 9.0 µM, 0.6 µM, 2.6 µM, 1.7 µM, 27.5 µM and 12.1 µM, respectively) and PI 3-Kα and PIM-1 (IC50 = 1.8 µM and 0.78 µM). Reported to inhibit the activities of phosphodiesterase 1-4 (IC50 < 40 µM) and MMP-2 (IC50 < 24 µM in several colorectal carcinoma cells), and block TNFα-mediated NF-κB signaling (at 50 µM in ECV304 cells) and insulin-stimulated glucose transport (Ki = ~ 33.5 µM in rat adipocytes). Further, induce apoptosis in HL-60 leukemia cells with an IC50 of 43 µM. 产品目录编号 476275 品牌系列 Calbiochem®
同义词 3,3ʹ,4ʹ,5,5ʹ,7-Hexahydroxyflavone, Hsp70 Inhibitor II 参考 参考 Lee, K.W., et al. 2007. Carcinogenesis 28, 1918.
Holder, S., et al. 2007. Mol. Cancer Ther. 6, 163.
Strobel, P., et al. 2005. Biochem. J. 386, 471.
Ko, C.H., et al. 2005. Mol. Cancer Ther. 4, 281.
Ko, C.H., et al. 2005. Biochem. Pharmacol. 69, 913.
Ko, W.C., et al. 2004. Biochem. Pharmacol. 68, 2087.
Walker, E.H., et al. 2000. Mol. Cell 6, 909.
Agullo, G., et al. 1997. Biochem. Pharmacol. 53, 1649.
Hagiwara, M., et al. 1988. Biochem. Pharmacol. 37, 2987.产品信息 CAS号 529-44-2 形式 Yellowish brown solid Hill配方 C₁₅H₁₀O₈ 化学配方 C₁₅H₁₀O₈ Molar Mass 318.2 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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