merck millipore,默克密理愽
  • merck millipore,默克密理博,46-656MAG,MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex

  • merck millipore,默克密理博,46-656MAG,MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex

    产品名称：MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex
    产品型号：46-656MAG
    This MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate Cell Signaling Single Plexhas the analyte Cleaved PARP.

    merck millipore,默克密理博,46-656MAG,MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex

  • 产品介绍
  • merck millipore,默克密理博,46-656MAG,MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex

    重要规格表

    可用的分析物 品种反应性 主要应用 检测方法
    PARP (Cleaved)HMplexLuminex xMAP
    描述
    产品目录编号 46-656MAG
    商名
    • MILLIPLEX
    描述 MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex
    概述 Apoptosis, programmed cell death, is a tightly controlled process involved in both embryonic development and adult homeostasis in which the body is able to rid itself of damaged or unnecessary cells without inducing an inflammatory response. This essential process is triggered by both internal (DNA damage, mitochondrial dysfunction) and external (Fas and TNF receptor) signals. Dysregulated apoptosis that results in accelerated programmed cell death has been implicated in the development of various neurological diseases, such as Alzheimer’s and Parkinson’s disease, while inhibition of apoptosis is involved in the development of autoimmune disorders and cancer.
    背景信息 Cleaved PARP
    • Also known as Poly (ADP-ribose) polymerase
    • Involved in programmed cell death and DNA repair
    • PARP is inactivated by caspase cleavage at aspartic acid 214 and glycine 215, separating PARP into 2 segments; this Cleaved PARP ends at Asp 214, and contains the DNA binding domain
    产品信息
    检测方法 Luminex xMAP
    配置 Single Plex
    板面类型 Cell Signaling
    应用
    应用 This MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate Cell Signaling Single Plexhas the analyte Cleaved PARP.
    主要应用
    • Multiplexing
    应用说明 • An overnight (4°C) incubation is recommended for best results
    • These assays require 25 µL diluted cell lysate per well
    • Please consult the buffer compatibility chart or protocol for appropriate buffer choice
    • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)
    生物信息
    品种反应性 Human
    可用的分析物
    • PARP (Cleaved)
    Entrez基因编号
    • NM_001618
    Entrez基因汇总 This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes.
    基因符号
    • PPOL
    • PARP1
    • poly(ADP-ribosyl)transferase
    • PARP-1
    • PARP
    • NAD
    • pADPRT-1
    • ADPRT1
    • Poly
    • ADPRT
    UniProt编号
    • P09874
    UniProt汇总 FUNCTION: SwissProt: P09874 # Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks.
    SIZE: 1014 amino acids; 113084 Da
    SUBUNIT: Component of a base excision repair (BER) complex, containing at least XRCC1, PARP2, POLB and LIG3. Homo- and heterodimer with PARP2. Interacts with PARP3, APTX and SRY. The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70. Interacts with ZNF423 (By similarity).
    SUBCELLULAR LOCATION: Nucleus.
    PTM: Phosphorylated by PRKDC. Phosphorylated upon DNA damage, probably by ATM or ATR. & Poly-ADP-ribosylated by PARP2.
    SIMILARITY: SwissProt: P09874 ## Contains 1 BRCT domain. & Contains 1 PARP alpha-helical domain. & Contains 1 PARP catalytic domain. & Contains 2 PARP-type zinc fingers.
    MISCELLANEOUS: The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor carboxyl group on a histone or the enzyme itself, and further ADP-ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    包装信息
    数量 96-well plate

    merck millipore,默克密理博,46-656MAG,MILLIPLEX MAP Cleaved PARP Magnetic Bead MAPmate - Cell Signaling Single Plex

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