merck millipore,默克密理博,46-618MAG,MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate

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merck millipore,默克密理博,46-618MAG,MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate - Cell Signaling Single Plex
产品名称：MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate - Cell Signaling Single Plex
产品型号：46-618MAG
This MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate is a Cell Signaling Single Plex. The analyte available for this kit is JNK/SAPK1 (Total).

merck millipore,默克密理博,46-618MAG,MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate - Cell Signaling Single Plex

产品介绍

merck millipore,默克密理博,46-618MAG,MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate - Cell Signaling Single Plex

重要规格表

可用的分析物	品种反应性	主要应用	检测方法
JNK/SAPK1 (Total)	M, H	Mplex	Luminex xMAP

描述
产品目录编号	46-618MAG
商名	MILLIPLEX
描述	MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate - Cell Signaling Single Plex

产品信息
检测方法	Luminex xMAP
配置	Single Plex
板面类型	Cell Signaling

应用
应用	This MILLIPLEX MAP Total JNK/SAPK1 Magnetic Bead MAPmate is a Cell Signaling Single Plex. The analyte available for this kit is JNK/SAPK1 (Total).
主要应用	Multiplexing
应用说明	• An overnight (4°C) incubation is recommended for best results • This assay requires 25 µL diluted cell lysate per well • Please consult the buffer compatibility chart or protocol for appropriate buffer choice • 1 - 25 μg cell lysate/well (recommended starting concentration is 20 μg)

生物信息
品种反应性	MouseHuman
可用的分析物	JNK/SAPK1 (Total)
Entrez基因编号	NM_139049.1 NM_002750.2 NM_139046.1 NM_139047.1
Entrez基因汇总	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
基因符号	JNK MAPK8 PRKM8 JNK-46 SAPK1 JNK1A2 JNK1 JNK21B1/2
UniProt编号	P45983
UniProt汇总	FUNCTION: SwissProt: P45983 # JNK1 isoforms display different binding patterns: beta-1 preferentially binds to c-Jun, whereas alpha-1, alpha-2, and beta- 2 have a similar low level of binding to both c-Jun or ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. COFACTOR: Magnesium. SIZE: 427 amino acids; 48296 Da SUBUNIT: Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with TP53 and WWOX. Interacts with JAMP (By similarity). DOMAIN: SwissProt: P45983 The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. PTM: Dually phosphorylated on Thr-183 and Tyr-185, which activates the enzyme. SIMILARITY: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. & Contains 1 protein kinase domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.