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merck millipore,默克密理博,454862,MNK1/2 Inhibitor II, ETP-45835 - Calbiochem
产品名称：MNK1/2 Inhibitor II, ETP-45835 - Calbiochem
产品型号：454862
The MNK1/2 Inhibitor II, ETP-45835 controls the biological activity of MNK1/2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
merck millipore,默克密理博,454862,MNK1/2 Inhibitor II, ETP-45835 - Calbiochem
- 产品介绍
重要规格表
经验配方 C₁₃H₁₆N₄•2HCl 描述 概述 A cell-permeable 3,5-disubstituted pyrazolo compound that acts as a selective MNK inhibitor (IC50 = 646 and 575 nM, respectively, against MNK1 and MNK2) with much reduced or little activity against 24 other kinases (≤15% inhibition at 5 µM). Reported to exhibit good aqueous solubility (> 100 µM at pH 7.4) and inhibit the proliferation (IC50 = 17 µM) and cellular eIF4E Ser209 phosphorylation (IC50 = 4.7 µM) of MV4:11 cells. 产品目录编号 454862 品牌系列 Calbiochem®
同义词 ETP45835, MNK Inhibitor II, Mitogen-Activated Protein Kinase-Interacting Kinase Inhibitor II, 4-(3-(Piperidin-4-yl)-1H-pyrazol-5-yl)pyridine, diHCl 参考 参考 Oyarzabal, J., et al. 2010. J. Med. Chem. 53, 6618. 产品信息 形式 White solid Hill配方 C₁₃H₁₆N₄•2HCl 化学配方 C₁₃H₁₆N₄•2HCl Molar Mass 301.2 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 H₂O 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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