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merck millipore,默克密理博,448104,c-Met/RON Dual Kinase Inhibitor - CAS 913376-84-8 - Calbiochem
产品名称：c-Met/RON Dual Kinase Inhibitor - CAS 913376-84-8 - Calbiochem
产品型号：448104
The c-Met/RON Dual Kinase Inhibitor, also referenced under CAS 913376-84-8, controls the biological activity of c-Met/RON.
merck millipore,默克密理博,448104,c-Met/RON Dual Kinase Inhibitor - CAS 913376-84-8 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₃₁H₂₉FN₄O₅ 913376-84-8 描述 概述 A cell-permeable quinoline compound that acts as a potent inhibitor against the kinase activities of HGF (Cat. No. 375228) receptor c-Met and MSP (Macrophage Stimulating Protein) receptor RON (IC50 = 4 and 9 nM, respectively), while exhibiting much weaker potency toward Lck, Tie2, Src, BTK, IGFR, or VEGFR2 (IC50 = 160, 400, 410, 710, 1000, and 1900 nM, respectively), and little or no activity against B-Raf and more than 20 other kinases IC50 >1 µM). Shown to effectively supress (IC50 <100 nM) the ligand-induced autophosphorylations of wild-type c-Met (in HT-29 and BxPC3 cultures) and RON (in NIH3T3 RON and BxPC3 cultures) as well as the ligand-independent autophosphorylations of the constitutively active mutants TPR-Met and RONΔ160 (in NIH3T3 TRP-Met and HT-29 cultures, respectively). Reported to inhibit NIH3T3 TRP-Met and U-87 tumor growth in mice in vivo in a dose-dependent manner (complete inhibition via daily p.o. dose of 100 mg/kg), but is less efficacious against HT-29, whose in vivo tumor growth is also dependent on V600E B-raf. 产品目录编号 448104 品牌系列 Calbiochem®
同义词 N-(3-Fluoro-4-(7-methoxy-4-quinolinyl)phenyl)-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-phenyl-2,3-dihydro-1H-pyrazole carboxamide, Compound I, Met Kinase Inhbitor IV, Ron Inhibitor I 参考 参考 Zhang, Y., et al. 2008. Cancer Res. 68, 6680. 产品信息 CAS号 913376-84-8 形式 Light tan solid Hill配方 C₃₁H₂₉FN₄O₅ 化学配方 C₃₁H₂₉FN₄O₅ Molar Mass 556.6 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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