merck millipore,默克密理愽
  • merck millipore,默克密理博,444937,MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

  • merck millipore,默克密理博,444937,MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

    产品名称：MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv
    产品型号：444937
    The MEK Inhibitor I, also referenced under CAS 297744-42-4, controls the biological activity of MEK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation application More>>

    merck millipore,默克密理博,444937,MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

  • 产品介绍
  • merck millipore,默克密理博,444937,MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

    重要规格表

    经验配方 CAS号
    C₂₁H₁₈N₄OS297744-42-4
    描述
    概述 A cell-permeable pyridine-containing vinylogous cyanamide compound that acts as a potent and selective inhibitor of MEK (IC50 = 12 nM) with little activity towards MKK3 and MKK4 (IC50 > 1 µM). The inhibition is noncompetitive with respect to ERK and the compound displays significant affinity only towards ATP-bound MEK (i.e. noncompetitive with respect to ATP). Exhibits superior potency, solubility, and stability compared to U0126 (Cat. No. 662005) in aqueous solutions. Shown to protect against phorbol ester-mediated ear edema in mice (ED50 of 5 mg/kg, ip.).
    产品目录编号 444937
    品牌系列 Calbiochem®
    参考
    参考 Wityak, J., et al. 2004. Bioorg. Med. Chem. Lett. 14, 1483.
    产品信息
    CAS号 297744-42-4
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₂₁H₁₈N₄OS
    化学配方 C₂₁H₁₈N₄OS
    Molar Mass 374.5
    可逆 N
    结构配方图像
    生物信息
    主靶 MEK
    主靶IC50 12 nM against MEK
    纯度 ≥ 95% by HPLC (sum of two isomers)
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or MeOH
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444937,MEK Inhibitor I - CAS 297744-42-4 - Calbiochemv

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