merck millipore,默克密理愽
  • merck millipore,默克密理博,444143,MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

  • merck millipore,默克密理博,444143,MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

    产品名称：MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem
    产品型号：444143
    The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Cancer applications.

    merck millipore,默克密理博,444143,MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,444143,MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₃₀H₃₀Cl₂N₄O₄548472-68-0
    描述
    概述 A cell-permeable cis-imidazoline compound that acts as a potent and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) and displays antitumor properties. Activates p53 pathway by binding MDM2 in the p53-binding pocket and inhibits MDM2-p53 interaction. Shown to suppress tumor growth by induction of apoptosis in several cancer cells with wild-type p53 and in xenografted tumor mice. A 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444151) in DMSO is also available.
    产品目录编号 444143
    品牌系列 Calbiochem®
    同义词 MDM2 Inhibitor IV
    参考
    参考 Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
    Vassilev, L.T., et al. 2004. Science 303, 844.
    产品信息
    CAS号 548472-68-0
    具有ATP竞争性 N
    形式 Solid
    Hill配方 C₃₀H₃₀Cl₂N₄O₄
    化学配方 C₃₀H₃₀Cl₂N₄O₄
    Molar Mass 581.5
    可逆 N
    结构配方图像
    生物信息
    主靶 MDM2
    主靶IC50 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b
    纯度 ≥98% by TLC and HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Harmful
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot, purge with inert gas, and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,444143,MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem

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