merck millipore,默克密理愽
  • merck millipore,默克密理博,440203,LY 303511 - CAS 154447-38-8 - Calbiochem

  • merck millipore,默克密理博,440203,LY 303511 - CAS 154447-38-8 - Calbiochem

    产品名称：LY 303511 - CAS 154447-38-8 - Calbiochem
    产品型号：440203
    A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002.

    merck millipore,默克密理博,440203,LY 303511 - CAS 154447-38-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,440203,LY 303511 - CAS 154447-38-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₈N₂O₂154447-38-8
    描述
    概述 A cell-permeable negative control for the PI 3-kinase inhibitor LY 294002 (Cat. No. 440202). Contains a single atom substitution in the morpholine ring compared to LY 294002. Does not inhibit PI 3-kinase even at a concentration of 100 µM. Shown to bind to the same site as I-BET (Cat. no. 401010) and reversibly inhibit BET bromodomain proteins BRD2, BRD3 & BRD4 (IC50 ~10 µM).
    产品目录编号 440203
    品牌系列 Calbiochem®
    同义词 2-Piperazinyl-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor V, BRD3 Inhibitor IV, BRD4 Inhibitor V
    参考
    参考 Dittman, et al. 2014. ACS Chem Biol. 9, 495.
    Ding, J., et al. 1995. J. Biol. Chem. 270, 11684.
    Vlahos, C.J., et al. 1994. J. Biol. Chem. 269, 5241.
    产品信息
    CAS号 154447-38-8
    具有ATP竞争性 N
    形式 Amber solid
    Hill配方 C₁₉H₁₈N₂O₂
    化学配方 C₁₉H₁₈N₂O₂
    Molar Mass 306.4
    可逆 N
    结构配方图像
    生物信息
    主靶 Negative control for the PI 3-kinase inhibitor LY 294002
    主靶IC50 Does not inhibit PI 3-kinase even at a concentration of 100 µM
    纯度 ≥98% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

    merck millipore,默克密理博,440203,LY 303511 - CAS 154447-38-8 - Calbiochem

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