merck millipore,默克密理愽
  • merck millipore,默克密理博,428207,Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem

  • merck millipore,默克密理博,428207,Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem

    产品名称：Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem
    产品型号：428207
    The Lck Inhibitor III, also referenced under CAS 1188890-30-3, controls the biological activity of Lck.

    merck millipore,默克密理博,428207,Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,428207,Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₂₈N₆O₃ • H₂O1188890-30-3
    描述
    概述 A cell-permeable, ATP binding site-targeting, tri-substituted pyrimidine that acts as a Lck (lymphocyte specific kinase) inhibitor (IC50 = 867 nM; [ATP] = 10 µM). Shown to block IL-2 release in Jurkat E6-1 T cell line (IC50 = 1.27 µM) stimulated by CD3 cross-linking and PMA. Although less potent than Lck Inhibitor II (Cat. No. 428206), it exhibits much improved aqueous solubility (27 µg/ml in 50 mM PBS, pH 7.4, ionic strength 0.15 M) and in vivo bioavailability (F = 22%, p.o. and i.v. at 10 mg/kg).
    产品目录编号 428207
    品牌系列 Calbiochem®
    同义词 2-(1H-Benzo[d]imidazol-1-yl)-N-(5-methoxy-2-methylphenyl)-6-(2-morpholinoethoxy)pyrimidin-4-amine, hydrate
    参考
    参考 Sabat, M., et al. 2006. Bioorg. Med. Chem. Lett. 16, 5973.
    产品信息
    CAS号 1188890-30-3
    形式 Off-white solid
    Hill配方 C₂₅H₂₈N₆O₃ • H₂O
    化学配方 C₂₅H₂₈N₆O₃ • H₂O
    Molar Mass 478.5
    结构配方图像
    生物信息
    纯度 ≥97% by HPLC
    理化信息
    溶解度 DMSO or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,428207,Lck Inhibitor III - CAS 1188890-30-3 - Calbiochem

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