merck millipore,默克密理博,422689,Kir2.1 Inhibitor, ML133 - CAS 185669-79-8

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Merck Millipore 默克密理愽

merck millipore,默克密理博,422689,Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

经验配方	CAS号
C₁₉H₁₉NO	185669-79-8

描述
概述	A cell-permeable, renal outer medullary potassium (ROMK) blocker that is shown to inhibit inward rectifier potassium channel, K_ir2.1 (IC₅₀ = 1.8 µM and 290 nM, at pH 7.4 and pH 8.5, respectively). It exhibits little selectivity against other members of the K_ir2.x family, but has no effect on K_ir1.1 (IC₅₀ > 300 µM) and displays weak activity for K_ir4.1 and K_ir7.1 (IC₅₀ = 76 µM and 33 µM, respectively). It is reported to be assayed in 218 MLPCN HTS campaigns, demonstrating activity in only two assays that are not based on K_ir2.1. Furthermore, it displays a relatively clean profile in a radioligand binding panel of 68 GPCRs, ion channels and transporters.
产品目录编号	422689
品牌系列	Calbiochem®
同义词	Inward rectifier potassium channel blocker, ML133

参考
参考	Lindsley, C.W., et al. 2011. ACS Chem. Biol. 6, 845.

生物信息
纯度	≥95% by HPLC

理化信息
溶解度	DMSO

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	+2°C to +8°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

包装信息
惰性气体下包装	Packaged under inert gas

merck millipore,默克密理博,422689,Kir2.1 Inhibitor, ML133 - CAS 185669-79-8 - Calbiochem

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