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merck millipore,默克密理博,420140,JNK Inhibitor X, BI-78D3 - CAS 883065-90-5 - Calbiochem
产品名称：JNK Inhibitor X, BI-78D3 - CAS 883065-90-5 - Calbiochem
产品型号：420140
The JNK Inhibitor X, BI-78D3, also referenced under CAS 883065-90-5, controls the biological activity of JNK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation ap More>>
merck millipore,默克密理博,420140,JNK Inhibitor X, BI-78D3 - CAS 883065-90-5 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₁₃H₉N₅O₅S₂ 883065-90-5 描述 概述 A cell-permeable benzodioxin-triazole compound that competes with JNK-interacting protein-1 (IC50 = 500 nM in competitive binding to JNK1 with pepJIP1) and D-domain-containing substrates binding (Ki = 200 nM in competitive binding to JNK1 with ATF2) by targeting JNK JIP1-interacting site (Kd = 8.1 µM). BI-78D3 inhibits the phosphorylation of ATF2, but not that of a D-domain-less peptide substrate, by JNK1 in kinase assays, while showing 100-fold less potency against p38α and no effect against mTOR or PI3-Kα. Shown to inhibit the TNF-α-stimulated GFP-cJun phosphorylation in transfected HeLa cultures in vitro (IC50 = 12.4 µM) and effectively reduce ConA-induced murine liver failure (10 mg/kg, i.p.) as well as restore insulin sensitivity in a murine type 2 diabetes model (25 mg/kg, i.p.) in vivo. 产品目录编号 420140 品牌系列 Calbiochem®
同义词 4-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-5-(5-nitrothiazol-2-ylthio)-4H-1,2,4-triazol-3-ol 参考 参考 Stebbins, J.L., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 16809. 产品信息 CAS号 883065-90-5 形式 Pale yellow solid Hill配方 C₁₃H₉N₅O₅S₂ 化学配方 C₁₃H₉N₅O₅S₂ Molar Mass 379.4 结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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