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merck millipore,默克密理博,06-597,Anti-phospho-Histone H1 Antibody
产品名称：Anti-phospho-Histone H1 Antibody
产品型号：06-597
Anti-phospho-Histone H1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of phospho-Histone H1 & has been validated in ICC & WB.
merck millipore,默克密理博,06-597,Anti-phospho-Histone H1 Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H, B WB, ICC Rb Purified Polyclonal Antibody 描述 产品目录编号 06-597 品牌系列 Upstate
商名 - Upstate
描述 Anti-phospho-Histone H1 Antibody 背景信息 Histone H1 is one of the five main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N-terminal tail, H1 is involved with the structure of the nucleosomes of the 'beads on a string' structure.
The N-terminal tail of histone H1 protrudes from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. These modifications include the covalent attachment of methyl or acetyl groups to lysine and arginine amino acids and the phosphorylation of serine or threonine.产品信息 格式 Purified 控制 - Colcemid treated HeLa cell lysate
演示 Immunoaffinity Purified immunoglobulin in 0.02M Phosphate Buffer, 0.25 M NaCl, pH 7.6 with 15 mg/mL BSA containing no preservatives. 应用 应用 Anti-phospho-Histone H1 Antibody is a high quality Rabbit Polyclonal Antibody for the detection of phospho-Histone H1 & has been validated in ICC & WB. 主要应用 - Western Blotting
- Immunocytochemistry
生物信息 免疫原品种 Hyper-phosphorylated isoform of tetrahymena Histone H1 purified by cation-exchange HPLC 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes phospho-Histone H1, Mr 32 kDa. Additional proteins were also detected, Mr 66 and 100 kDa. 同种型 IgG 品种反应性 HumanBovine 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005319
Entrez基因汇总 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. 基因符号 - H1.2
- HIST1H1C
- MGC3992
- H1F2
修改 - Phosphorylation
纯化方法 Protein A purfied UniProt编号 - P16403
UniProt汇总 FUNCTION: SwissProt: P16403 # Histones H1 are necessary for the condensation of nucleosome chains into higher order structures.
SIZE: 213 amino acids; 21365 Da
SUBCELLULAR LOCATION: Nucleus.
SIMILARITY: SwissProt: P16403 ## Belongs to the histone H1/H5 family.产品使用声明 质量保证 Immunoblot Analysis: 0.5-2 μg/mL detected phosphorylated Histone H1 from acid extracts of colcemid treated HeLa cells but not untreated HeLa cells (Catalog # 17-306).
Immunocytochemistry: 5-10 μg/mL showed positive immunostaining for Histone H1 in mitotic HeLa cells fixed with 95% ethanol/5% glacial acetic acid (v/v).使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 200 µg
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