merck millipore,默克密理愽
  • merck millipore,默克密理博,420121,JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

  • merck millipore,默克密理博,420121,JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

    产品名称：JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem
    产品型号：420121
    The JAK3 Inhibitor IV, also referenced under CAS 58753-54-1, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicati More>>

    merck millipore,默克密理博,420121,JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420121,JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₃H₂₅NO · HCl58753-54-1
    描述
    概述 A (β-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25°C, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1].
    产品目录编号 420121
    品牌系列 Calbiochem®
    同义词 2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923
    参考
    参考 Brown, G.R., et al. 2000. Bioorg. Med. Chem. Lett. 10, 575.
    产品信息
    CAS号 58753-54-1
    具有ATP竞争性 Y
    声明 Sold under license of PCT Application W098/22,103.
    形式 White crystalline solid
    Hill配方 C₂₃H₂₅NO · HCl
    化学配方 C₂₃H₂₅NO · HCl
    Molar Mass 367.9
    吸湿 Hygroscopic
    可逆 N
    结构配方图像
    生物信息
    主靶 JAK-3
    主靶IC50 pIC50 = 7.1 against JAK3
    纯度 ≥99% by HPLC
    理化信息
    细胞可渗透 N
    溶解度 DMSO
    储存和货运信息
    货运代码 Blue Ice Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420121,JAK3 Inhibitor IV - CAS 58753-54-1 - Calbiochem

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