merck millipore,默克密理愽
  • merck millipore,默克密理博,420104,JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

  • merck millipore,默克密理博,420104,JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

    产品名称：JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem
    产品型号：420104
    The JAK3 Inhibitor II, also referenced under CAS 211555-04-3, controls the biological activity of JAK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applicat More>>

    merck millipore,默克密理博,420104,JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,420104,JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₆H₁₄BrN₃O₃211555-04-3
    描述
    概述 A potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
    产品目录编号 420104
    品牌系列 Calbiochem®
    同义词 4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
    参考
    参考 Ghosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
    Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
    Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
    Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.
    产品信息
    CAS号 211555-04-3
    具有ATP竞争性 Y
    形式 Pale yellow solid
    Hill配方 C₁₆H₁₄BrN₃O₃
    化学配方 C₁₆H₁₄BrN₃O₃
    Molar Mass 376.2
    可逆 Y
    结构配方图像
    生物信息
    主靶 JAK-3
    主靶IC50 5.6 µM against JAK3
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,420104,JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

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