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经验配方 CAS号 C₂₉H₃₂N₄O₃S 422513-13-1 描述 概述 A cell-permeable indolinone compound that interacts with both the ATP- and the adjacent hydrophobic binding pocket of Aurora B and acts as a rapid and reversible inhibitor of Aurora kinase B activity (IC50 ~ 250 nM) with moderate selectivity over Cdk1/B, Cdk2/E and Cdk4/D1 (IC50 = 1.2, > 10 and > 10 µM). Also, potently inhibits several kinases at 1 µM in a 25-kinase screening panel (100%, 100%, 96%, 88%, 87% and 84% against Lck, PHK, AMPK, MKK1, MAPKAP-K1 and Chk1, respectively). Reported to reduce histone H3-Ser10 phosphorylation, inhibit cytokinesis, promote chromosome biorientation, perturb mitosis and polyploidy in mammalian cells. 产品目录编号 375680 品牌系列 Calbiochem®
同义词 Aurora Kinase Inhibitor X, AMPK Inhibitor II 参考 参考 Knowlton, A.L., et al. 2006. Curr. Biol. 16, 1705.
Kapoor, T.M., et al. 2006. Science 311, 388.
Hirota, T., et al. 2005. Nature 438, 1176.
Sessa, F., et al. 2005. Mol. Cell. 18, 379.
Lampson, M.A., et al. 2004. Nat. Cell Biol. 6, 232.
Hauf, S., et al. 2003. J. Cell Biol. 161, 281.产品信息 CAS号 422513-13-1 形式 Yellow solid Hill配方 C₂₉H₃₂N₄O₃S 化学配方 C₂₉H₃₂N₄O₃S Molar Mass 516.7 结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
毒性 Regulatory Review
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot freeze at -(20°C). Stock solutions are stable for up to 6 months at -20°C.. 包装信息 惰性气体下包装 Packaged under inert gas
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