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merck millipore,默克密理博,362330,GAG Antagonist, Surfen - Calbiochem
产品名称：GAG Antagonist, Surfen - Calbiochem
产品型号：362330
The GAG Antagonist, Surfen controls the biological activity of GAG. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
merck millipore,默克密理博,362330,GAG Antagonist, Surfen - Calbiochem
- 产品介绍
重要规格表
经验配方 C₂₁H₂₀N₆O • 2HCl • 3H₂O 描述 概述 A symmetrical quinolyl-urea compound that binds GAGs (glycosaminoglycans) via electrostatic interaction with the negatively charged sulfate and carboxyl moieties present in heparan sulfate (HS), heparin, and dermatan sulfate, resulting in effective blockage of GAGs interactions with their protein binding partners. Surfen is shown to effectively neutralize HS- and heparin-mediated thrombin inhibition of Factor Xa activity as well as heparin's anti-clotting activity. Also reported to inhibit FGF2-induced Erk phosphorylation and tubulation in murine lung endothelial cultures (IC50 ~5 µM), fibronectin HS-binding domain-dependent CHO cell adhesion (IC50 = 3 µM), and HSV-1 infection of glucosaminyl 3-O-sulfotransferase-3A-expressing CHO cells (complete inhibition at 5 µM). Surfen analogs with improved potency may serve as promising candidates as less toxic alternatives to Protamine (Cat. No. 539122) in clinical applications. 产品目录编号 362330 品牌系列 Calbiochem®
同义词 NSC12155, bis-2-Methyl-4-amino-quinolyl-6-carbamide, diHCl, trihydrate, Glycosaminoglycans Antagonist 参考 参考 Schuksz, M., et al. 2008. Proc. Natl. Acad. Sci. USA 105, 13074.
Hunter, D.T. Jr., and Hill, J.M. 1961. Nature 191, 1378.产品信息 形式 White solid Hill配方 C₂₁H₂₀N₆O • 2HCl • 3H₂O 化学配方 C₂₁H₂₀N₆O • 2HCl • 3H₂O Molar Mass 499.4 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥98% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot into glass vials and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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