merck millipore,默克密理愽
  • merck millipore,默克密理博,36-016,Anti-phospho-ATF2 (Thr69) Antibody

  • merck millipore,默克密理博,36-016,Anti-phospho-ATF2 (Thr69) Antibody

    产品名称：Anti-phospho-ATF2 (Thr69) Antibody
    产品型号：36-016
    Detect phospho-ATF2 (Thr69) with Anti-phospho-ATF2 (Thr69) Antibody (Sheep Polyclonal Antibody), that has been shown to work in EA.

    merck millipore,默克密理博,36-016,Anti-phospho-ATF2 (Thr69) Antibody

  • 产品介绍
  • merck millipore,默克密理博,36-016,Anti-phospho-ATF2 (Thr69) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HEAShPurifiedPolyclonal Antibody
    描述
    产品目录编号 36-016
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-phospho-ATF2 (Thr69) Antibody
    产品信息
    格式 Purified
    演示 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
    应用
    应用 Detect phospho-ATF2 (Thr69) with Anti-phospho-ATF2 (Thr69) Antibody (Sheep Polyclonal Antibody), that has been shown to work in EA.
    主要应用
    • Enzyme Assay
    生物信息
    免疫原品种 Synthetic peptide corresponding to amino acids surrounding phosphorylated Thr69 of human ATF2.
    宿主 Sheep
    特异性 ATF2 phosphorylated on Threonine 69.
    同种型 IgG
    品种反应性 Human
    Species Reactivity Note Predicted to cross-react with mouse and rat, based on sequence homology
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001880.2
    Entrez基因汇总 This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined.
    基因符号
    • HB16
    • CREBP1
    • CREB2
    • TREB7
    • ATF2
    • CRE-BP1
    • MGC111558
    修改
    • Phosphorylation
    纯化方法 Protein G purfied
    UniProt编号
    • P15336
    UniProt汇总 FUNCTION: SwissProt: P15336 # Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.
    SIZE: 487 amino acids; 52277 Da
    SUBUNIT: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.
    SUBCELLULAR LOCATION: Nucleus.
    TISSUE SPECIFICITY: Abundant expression seen in the brain.
    PTM: Phosphorylation of Thr-51 and Thr-53 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.
    SIMILARITY: SwissProt: P15336 ## Belongs to the bZIP family. ATF subfamily. & Contains 1 bZIP domain. & Contains 1 C2H2-type zinc finger.
    产品使用声明
    质量保证 Routinely evaluated by immunoblot on recombinant ATF2 (12-367), phosphorylated by JNK1/SAPK1c, active (14-327) using a cold kinase assay.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µg

    merck millipore,默克密理博,36-016,Anti-phospho-ATF2 (Thr69) Antibody

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