merck millipore,默克密理愽
  • merck millipore,默克密理博,36-012,Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14

  • merck millipore,默克密理博,36-012,Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14

    产品名称：Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14
    产品型号：36-012
    Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14 detects level of nitro-α/β-Synuclein (Tyr39) & has been published & validated for use in WB, IH.

    merck millipore,默克密理博,36-012,Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14

  • 产品介绍
  • merck millipore,默克密理博,36-012,Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIHC, WBMPurifiedMonoclonal Antibody
    描述
    产品目录编号 36-012
    品牌系列 Upstate
    商名
    • Upstate
    描述 Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14
    产品信息
    格式 Purified
    演示 ascites with 0.05% sodium azide
    应用
    应用 Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14 detects level of nitro-α/β-Synuclein (Tyr39) & has been published & validated for use in WB, IH.
    主要应用
    • Immunohistochemistry
    • Western Blotting
    生物信息
    免疫原品种 full-length recombinant human α-Synuclein nitrated in vitro
    克隆 clone nSyn14
    宿主 Mouse
    特异性 α- or β-synuclein nitrated at Tyr39
    品种反应性 Human
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NM_007308.1
    • NM_000345.2
    Entrez基因汇总 The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
    基因符号
    • Alpha-synuclein
    • SNCA
    • MGC110988
    • PD1
    • alpha-synuclein
    • NACP
    • PARK1
    • PARK4
    修改
    • Nitration
    纯化方法 Ascites
    UniProt编号
    • Q16143
    • P37840
    UniProt汇总 FUNCTION: SwissProt: Q16143 # Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6 hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    SIZE: 134 amino acids; 14288 Da
    SUBCELLULAR LOCATION: Cytoplasm.
    TISSUE SPECIFICITY: Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
    PTM: Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    DISEASE: SwissProt: Q16143 # Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCB is found in spheroids but not in inclusions.
    SIMILARITY: SwissProt: Q16143 ## Belongs to the synuclein family.
    产品使用声明
    质量保证 routinely evaluated by immunoblot on recombinant protein nitrated in vitro
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 2 years at -20°C
    包装信息
    数量 200 µL

    merck millipore,默克密理博,36-012,Anti-nitro-α/β-Synuclein (Tyr39) Antibody, clone nSyn14

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