merck millipore,默克密理博,345805,Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6

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merck millipore,默克密理博,345805,Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem
产品名称：Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem
产品型号：345805
A benzoquinoid antibiotic that inhibits p60c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells.

merck millipore,默克密理博,345805,Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem

产品介绍

merck millipore,默克密理博,345805,Geldanamycin, Streptomyces hygroscopicus - CAS 30562-34-6 - Calbiochem

重要规格表

经验配方	CAS号
C₂₉H₄₀N₂O₉	30562-34-6

描述
概述	A benzoquinoid antibiotic that inhibits p60^c-src tyrosine kinase and c-myc gene expression in murine lymphoblastoma cells. Geldanamycin has antiproliferative and antitumor effects. Rapidly depletes p185^c-erbB2 protein tyrosine kinase in breast carcinoma cells. Binds to HSP90 and disrupts Raf1-HSP90 complex leading to destabilization of Raf1. Inhibits basal and hypoxia-induced expression of c-Jun (IC₅₀ = 75 nM) and abolishes hypoxia-induced increase in c-Jun N-terminal kinase activity. Also known to selectively destabilize mutated p53 protein from a number of breast, leukemia, and prostate cell lines.
产品目录编号	345805
品牌系列	Calbiochem®

参考
参考	Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935. Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796. Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839. Blagosklonny, M.V., et al. 1995. Oncogene 11, 933. Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806. Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324. Yamaki, H., et al. 1989. J. Antibiot. 42, 604. Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.

参考

Vasilevskaya, I.A., and O’Dwyer, P.J. 1999. Cancer Res. 59, 3935.
Mimnaugh, E.G., et al. 1996. J. Biol. Chem. 271, 22796.
Schulte, T.W., et al. 1996. Mol. Cell. Biol. 16, 5839.
Blagosklonny, M.V., et al. 1995. Oncogene 11, 933.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
Whitesell, L., et all. 1994. Proc. Natl. Acad. USA 91, 8324.
Yamaki, H., et al. 1989. J. Antibiot. 42, 604.
Uehara, Y., et al. 1984. Mol. Cell. Biol. 6, 2198.

产品信息
CAS号	30562-34-6
具有ATP竞争性	N
形式	Yellow solid
Hill配方	C₂₉H₄₀N₂O₉
化学配方	C₂₉H₄₀N₂O₉
Molar Mass	560.6
可逆	N
结构配方图像

生物信息
主靶	pc60^c-svc tyrosine kinase
主靶IC₅₀	75 nM Inhibiting basal and hypoxia-induced expression of c-Jun
纯度	≥95% by HPLC

理化信息
细胞可渗透	N
溶解度	DMSO

GHS安全信息
RTECS	LX8920000

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Standard Handling
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.