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merck millipore,默克密理博,342001,Procathepsin K, Human, Recombinant, E. coli
产品名称：Procathepsin K, Human, Recombinant, E. coli
产品型号：342001
Recombinant, human procathepsin K expressed in E. coli with a methionine residue inserted at amino acid 18 to create a new N-terminal initiation site.
merck millipore,默克密理博,342001,Procathepsin K, Human, Recombinant, E. coli
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重要规格表
描述 概述 Recombinant, human procathepsin K (amino acids 19-329) (GenBank target symbol = S79895, ACC No. P43235) expressed in E. coli with a methionine residue inserted at amino acid 18 to create a new N-terminal initiation site. Cathepsin K, a member of the papain superfamily of cysteine proteinases, plays an important role in osteoclast-mediated bone resorption and collagen degradation. Cathepsin K is synthesized as an inactive proenzyme that is converted to its mature, active form by proteolytic cleavage of the 99 amino acid propeptide domain. Inhibitors of cathepsin K include leupeptin (Cat. No. 108975) (IC50 = 70 nM), E-64 (Cat. No. 324890) (IC50 = 5 nM), and cystatin (Cat. No. 324891 or 324896). Requires activation prior to use. If the activated enzyme is not used immediately, it is recommended to add methyl methanthiosulfonate (1 mM final concentration MMTS). Note: 1 mU = 1 milliunit. 产品目录编号 342001 品牌系列 Calbiochem®
参考 参考 McQueney, M., et al. 1997. J. Bio. Chem. 272, 13955.
Bossard, M., et al. 1996. J. Biol. Chem. 271, 12517.
Drake, F., et al. 1996. J. Biol. Chem. 271, 12511.
Bromme, D. and Okamoto, K. 1995. Biol. Chem. Hoppe-Seyler 376, 379.
Baron, R. 1989 Anat. Rec. 224, 317.
Littlewood-Evans, A.J., et al. 1975. Cancer Res. 57, 5386.
Nishimura, J.S. et al. 1975. Arch. Biochem. Biophys. 170, 461.产品信息 活性 ≥1000 mU/mg protein EC号 3.4.22.38 形式 Liquid 配方 In 500 mM NaCl, 25 mM Tris, pH 8.0. Molar Mass 35068 生物信息 纯度 ≥95% by SDS-PAGE 浓缩标签 Please refer to vial label for lot-specific concentration
储存和货运信息 货运代码 Dry Ice Only
毒性 Standard Handling
储存 ≤ -70°C
避免冻结 / 解冻 Avoid freeze/thaw
无需冷冻 No
特殊指南 Following initial thaw, aliquot and freeze (-70°C). Following activation the enzyme is unstable and should include MMTS for storage (see recommended reaction conditions for activation).
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