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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 07-1448 Replaces AB4095 描述 Anti-WAVE-1 Antibody Alternate Names - homology of dictyostelium scar 1
- Wiskott-Aldrich syndrome protein family member 1
- WASP family protein member 1
- WAS protein family, member 1
- Verprolin homology domain-containing protein 1
- Protein WAVE-1
背景信息 Recognizes WAVE1 (Wiskott-Aldrich syndrome protein family member 1, WASP-family protein member 1). WAVE1 is a downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. WAVE1 binds actin and ARP2/3 complex. It binds the ARP2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain. 产品信息 格式 Affinity Purified 控制 - RAW264.7 cell lysat
演示 Purified rabbit polyclonal in buffer containing 0.02M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide. 应用 应用 This Anti-WAVE-1 Antibody is validated for use in WB for the detection of WAVE-1. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to an internal amino acid sequence of human WAVE1. Immunogen sequence is conserved in rat and mouse. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes an internal amino acid sequence of WAVE-1. 品种反应性 MouseHuman Species Reactivity Note Reacts with mouse and human. Reactivity with other species has not been determined. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003922.1
Entrez基因汇总 The protein encoded by this gene, a member of the Wiskott-Aldrich syndrome protein (WASP)-family, plays a critical role downstream of Rac, a Rho-family small GTPase, in regulating the actin cytoskeleton required for membrane ruffling. It has been shown to associate with an actin nucleation core Arp2/3 complex while enhancing actin polymerization in vitro. Wiskott-Aldrich syndrome is a disease of the immune system, likely due to defects in regulation of actin cytoskeleton. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene. 基因符号 - FLJ31482
- KIAA0269
- OTTHUMP00000016990
- SCAR1
- WAVE
- WAVE1
纯化方法 Affinity Purfied UniProt编号 - Q92558
UniProt汇总 FUNCTION: Downstream effector molecules involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton.
SUBUNIT STRUCTURE: Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1 By similarity. Binds actin and the Arp2/3 complex. Interacts with BAIAP2.
SUBCELLULAR LOCATIION: Cytoplasm › cytoskeleton. Note: Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
TISSUE SPECIFICITY: Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
DOMAIN: Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
SEQUENCE SIMILARITIES: Belongs to the SCAR/WAVE family.
Contains 1 WH2 domain.产品使用声明 质量保证 Evaluated by Western Blot in RAW264.7 cell lysate.
Western Blot Analysis: A 1:500 dilution of this antibody detected WAVE-1 on 10 µg of RAW264.7 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at 2 -8ºC in undiluted aliquots for up to 12 months from date of receipt. 包装信息 数量 100 µg
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