merck millipore,默克密理愽
  • merck millipore,默克密理博,341220,Exo1 - CAS 75541-83-2 - Calbiochem

  • merck millipore,默克密理博,341220,Exo1 - CAS 75541-83-2 - Calbiochem

    产品名称：Exo1 - CAS 75541-83-2 - Calbiochem
    产品型号：341220
    A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells by inducing tubulation and collapsing of the Golgi membrane.

    merck millipore,默克密理博,341220,Exo1 - CAS 75541-83-2 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,341220,Exo1 - CAS 75541-83-2 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₅H₁₂FNO₃75541-83-2
    描述
    概述 A cell-permeable methylanthranilate analog that reversibly inhibits vesicular traffic from ER to Golgi in mammalian cells (IC50 = 20 µM in BSC1 cells) by inducing tubulation and collapsing of the Golgi membrane and redirecting the traffic back to ER. Acts as a potent and selective modifier of Golgi ARF1 GTPase activity. Unlike another membrane traffic inhibitor Brefeldin A (BFA; Cat. No. 203729), its effect seems to be limited to Golgi, as no effect can be detected on endocytic organelles, such as endosomes and TGN (trans-Golgi network). Its inhibitory mechanism and target(s) appear to be quite different from those of BFA and thus serves as a valuable alternative that complements BFA in membrane traffic studies.
    产品目录编号 341220
    品牌系列 Calbiochem®
    同义词 2-(4-Fluorobenzoylamino)methylbenzoate, 2-(4-Fluorobenzoylamino)benzoic Acid Methyl Ester, ER Export Inhibitor I
    参考
    参考 Feng. Y., et al. 2003. Proc. Natl. Acad. Sci. USA 100, 6469.
    产品信息
    CAS号 75541-83-2
    具有ATP竞争性 N
    形式 White solid
    Hill配方 C₁₅H₁₂FNO₃
    化学配方 C₁₅H₁₂FNO₃
    Molar Mass 273.3
    可逆 Y
    结构配方图像
    生物信息
    主靶 Golgi ARF1 GTPase
    主靶IC50 20 µM inhibiting vesicular traffic from ER to Golgi in BSC1 cells
    纯度 ≥95% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO, DMF, MeOH, or EtOH
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,341220,Exo1 - CAS 75541-83-2 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,ECM512,QCM Chemotaxis Cell Migration Assay, 96-well (5 µm), fluorimetric
下一件merck millipore产品：merck millipore,默克密理博,211280,Capsazepine - CAS 138977-28-3 - Calbiochem


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