merck millipore,默克密理愽
  • merck millipore,默克密理博,341216,Ezrin Inhibitor, NSC668394 - Calbiochem

  • merck millipore,默克密理博,341216,Ezrin Inhibitor, NSC668394 - Calbiochem

    产品名称：Ezrin Inhibitor, NSC668394 - Calbiochem
    产品型号：341216
    The Ezrin Inhibitor, NSC668394 controls the biological activity of Ezrin.

    merck millipore,默克密理博,341216,Ezrin Inhibitor, NSC668394 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,341216,Ezrin Inhibitor, NSC668394 - Calbiochem

    重要规格表

    经验配方
    C₁₇H₁₂Br₂N₂O₃
    描述
    概述 A cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
    产品目录编号 341216
    品牌系列 Calbiochem®
    同义词 7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
    参考
    参考 Bulut, G., et al. 2011. Oncogene 31, 269.
    产品信息
    形式 Reddish orange solid
    Hill配方 C₁₇H₁₂Br₂N₂O₃
    化学配方 C₁₇H₁₂Br₂N₂O₃
    Molar Mass 449.9
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped with Blue Ice or with Dry Ice
    毒性 Standard Handling
    储存 -20°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,341216,Ezrin Inhibitor, NSC668394 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,539183,Proteasome Inhibitor VIII, β-Lactam 3 - CAS 870528-53-3 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,322133,DSP, Water-Soluble


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