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merck millipore,默克密理博,328008,ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem
产品名称：ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem
产品型号：328008
The ERK Inhibitor II, Negative Control, also referenced under CAS 1177970-73-8, controls the biological activity of ERK. This small molecule/inhibitor is primarily used for Phosphorylation & Dephospho More>>
merck millipore,默克密理博,328008,ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem
- 产品介绍
- merck millipore,默克密理博,328008,ERK Inhibitor II, Negative Control, FR180209 - CAS 1177970-73-8 - Calbiochem
重要规格表
经验配方 CAS号 C₁₈H₁₂N₆O 1177970-73-8 描述 概述 A cell-permeable Erk Inhibitor II (Cat. No. 328007) structural analog that acts as a isoform-selective Aurora B kinase inhibitor (95% inhibition at 1 µM; [ATP] = 10 µM) with little or no activity against Aurora A or C (0% and 16% inhibition, respectively, at 1 µM; [ATP] = 15 µM), Also shown to inhibit Chk2, IRR/INSRR, and Ack1/TNK2 (% inhibition/[ATP] = 81%/70 µM, 75%/200 µM, and 71%/70 µM, respectively), while exhibiting much reduced or no inhibitory potency toward a panel of 228 other kinases, including Erk1/2. 产品目录编号 328008 品牌系列 Calbiochem®
同义词 5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ol, Chk2 Inhibitor IV, Aurora Kinase Inhibitor XII, Irfin1, Insulin Receptor Family Inhibitor 参考 参考 Anastassiadis, T., et al. 2013. J. Biol. Chem. 288, In press.
Gao, Y., et al. 2013. Biochem. J. in press.
Ohori, M., et al. 2005. Biochem. Biophys. Res. Commun. 336, 357.产品信息 CAS号 1177970-73-8 具有ATP竞争性 N 形式 Green solid Hill配方 C₁₈H₁₂N₆O 化学配方 C₁₈H₁₂N₆O Molar Mass 328.3 可逆 N 结构配方图像 生物信息 主靶 Aurora B kinase 主靶IC50 95% inhibition at 10 µM using 1 µM; [ATP] 纯度 ≥98% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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