merck millipore,默克密理愽
  • merck millipore,默克密理博,324832,EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

  • merck millipore,默克密理博,324832,EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

    产品名称：EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem
    产品型号：324832
    The EGFR Inhibitor II, BIBX1382, also referenced under CAS 196612-93-8, controls the biological activity of EGFR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylatio More>>

    merck millipore,默克密理博,324832,EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,324832,EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O196612-93-8
    描述
    概述 A cell-permeable pyrimidopyrimidine compound that acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of EGFR (ErbB-1, HER-1) both in cell-free enzymatic reactions (IC50 = 3 nM) and in culture (IC50 = 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells). It exhibits 1,000-fold greater selectivity over ErbB-2 (HER-2, neu; IC50 = 3.4 µM) and shows little activity towards IGF1R, β-InsRK, HGFR, c-src, and VEGFR-2 even at concentrations as high as 10 µM. Its antitumor efficacy has also been demonstrated in a murine xenograft model in vivo (10 mg/kg, daily, p.o.).
    产品目录编号 324832
    品牌系列 Calbiochem®
    同义词 N⁸-(3-Chloro-4-fluorophenyl)-N²-(1-methylpiperidin-4-yl)-pyrimido[5,4-d]pyrimidine-2,8-diamine, 2HCl, BIBX1382BS
    参考
    参考 Solca, F.F., et al. 2004. J. Pharm. Exp. Ther. 311, 502.
    Egeblad, M., et al. 2001. Biochem. Biophys. Res. Commun. 281, 25.
    Nuijen, B., et al. 2000. Int. J. Pharm. 194, 261.
    产品信息
    CAS号 196612-93-8
    具有ATP竞争性 Y
    形式 Yellow solid
    Hill配方 C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O
    化学配方 C₁₈H₁₉ClFN₇ • 2HCl • 2H₂O
    Molar Mass 496.8
    吸湿 Hygroscopic
    可逆 Y
    结构配方图像
    生物信息
    主靶 EGFR (ErbB-1, HER-1)
    主靶IC50 3 nM against EGFR (ErbB-1, HER-1) in cell-free enzymatic reactions; 0.15, 1.82, and 3.2 µM in EGF-, HGF-, and FCS-dependent thymidine incorporation, respectively, in KB cells
    纯度 ≥97% by HPLC
    理化信息
    细胞可渗透 Y
    溶解度 DMSO or H₂O
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Irritant
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

    merck millipore,默克密理博,324832,EGFR Inhibitor II, BIBX1382 - CAS 196612-93-8 - Calbiochem

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