merck millipore,默克密理愽
  • merck millipore,默克密理博,526561,PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem

  • merck millipore,默克密理博,526561,PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem

    产品名称：PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem
    产品型号：526561
    The PI 3-K/mTOR Inhibitor III, PKI-179, also referenced under CAS 1197160-28-3, controls the biological activity of PI 3-K/mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & D More>>

    merck millipore,默克密理博,526561,PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,526561,PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₂₅H₂₈N₈O₃•H₂O1197160-28-3
    描述
    概述 A cell-permeable triazinyl-phenyl-pyridinylurea compound that acts as a potent inhibitor against mTOR (IC50 = 0.42 nM) and PI 3-K (IC50 = 8, 24, 74, 77, 14, and 11 nM against isoform α, β, γ, δ, α E545K mutant, and α H1047R mutant, respectively) activities, exhibiting much reduced or little activity against a panel of 361 other kinases (IC50 >50 µM), Cytochrome CYP isoforms, or hERG. It is reported to be orally available in mouse, rat, monkey, and dog species, and effectively suppress cancer growth both in cultures in vitro (IC50 = 22 and 29 nM, respectively, against MDA361 and PC3mm2) and in mice in vivo (by 30% of control MDA361 tumor size on day 42; 50 mg/kg/day p.o.) via apoptosis induction as a result of Akt/mTOR pathway inhibition.
    产品目录编号 526561
    品牌系列 Calbiochem®
    同义词 1-(4-(4-(3-Oxa-8-azabicyclo[3.2.1]octan-8-yl)-6-morpholino-1,3,5-triazin-2-yl)-phenyl)-3-(pyridin-4-yl)urea, hydrate, N-(4-(4-(4-Morpholinyl)-6-(3-oxa-8-azabicyclo[3.2.1]oct-8-yl)-1,3,5-triazin-2-yl)phenyl)-Nʹ-4-pyridinylurea, hydrate, mTOR Inhibitor X, PI 3-K Inhibitor XVII
    参考
    参考 Venkatesan, A.M., et al. 2010. Bioorg. Med. Chem. Lett. 20, 5869.
    Chen, Z., et al. 2010. J. Org. Chem. 75, 1643.
    产品信息
    CAS号 1197160-28-3
    形式 White solid
    Hill配方 C₂₅H₂₈N₈O₃•H₂O
    化学配方 C₂₅H₂₈N₈O₃•H₂O
    Molar Mass 506.6
    吸湿 Hygroscopic
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    吸湿 Hygroscopic
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,526561,PI 3-K/mTOR Inhibitor III, PKI-179 - CAS 1197160-28-3 - Calbiochem

上一件merck millipore产品：merck millipore,默克密理博,266785,Diacylglycerol Kinase Inhibitor I - CAS 93076-89-2 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ABS30,Anti-Sulfenic Acid Modified Cysteine (2-Thiodimedone-Specific Ig) Antibody


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