merck millipore,默克密理愽
  • merck millipore,默克密理博,509272,Hydroxychloroquine Sulfate - Calbiochem

  • merck millipore,默克密理博,509272,Hydroxychloroquine Sulfate - Calbiochem

    产品名称：Hydroxychloroquine Sulfate - Calbiochem
    产品型号：509272
    A cell-permeable compound that increases intralysosomal pH and impairs autophagic degradation process. Suppresses proliferation of human dermal fibroblasts (IC₅₀ = 30 µM).

    merck millipore,默克密理博,509272,Hydroxychloroquine Sulfate - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,509272,Hydroxychloroquine Sulfate - Calbiochem

    重要规格表

    经验配方
    C₁₈H₂₈ClN₃O₅S
    描述
    概述 A cell-permeable, orally available quinoline derivative with anti-malarial properties. Increases intralysosomal pH and thereby impairs autophagic degradation process. Reduces metabolic activity and suppresses proliferation of human dermal fibroblasts (IC50 = 30 µM). Shown to inhibit ERK1/2 phosphorylation (Thr202/Try204), but does not affect Akt and mTOR phosphorylation. Shown to directly block the binding of CXCL12 to CXCR4 and inhibit downstream effects in pancreatic cancer cells (EC50 = 9.8 µM). Effectively antagonizes CXCR4-mediated cell proliferation in PANC-1, Hs-766T, and MIAPaCa-2 cells. Suppresses Toll-like receptor 9 (TLR-9)-mediated dendritic cell activation and displays anti-inflammatory properties.

    Please note that the molecular weight for this compound is batch-specific due to variable water content.
    产品目录编号 509272
    品牌系列 Calbiochem®
    同义词 HCQ, Autophagy Inhibitor
    参考
    参考 Kim, J., et al. 2012. PLoS ONE. 7, e31004.
    Ramser, B., et al. 2009. J. Invest. Dermatol. 129, 2419.
    Boya., P., et al. 2005. Mol. Cell. Biol. 22, 1025.
    Oikarinen, A., et al. 2009. J. Invest. Dermatol. 129, 2333.
    Kuznik, A., et al. 2011. J. Immunol. 186, 4794.
    产品信息
    形式 Off-white powder
    Hill配方 C₁₈H₂₈ClN₃O₅S
    化学配方 C₁₈H₂₈ClN₃O₅S
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 H₂O
    安全信息
    R相 R: 22

    Harmful if swallowed.
    S相 S: 36/37/39

    Wear suitable protective clothing, gloves and eye/face protection.
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Harmful
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,509272,Hydroxychloroquine Sulfate - Calbiochem

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