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经验配方 CAS号 C₁₉H₁₂O₆ 66-76-2 描述 概述 A cell-permeable quinone reductase inhibitor with anticoagulant properties. Potentiates apoptosis by simultaneously blocking SAPK/JNK and NF-κB pathways. Does not affect phosphorylation of p38 or activation of AKT. Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells (IC50 = 180 µM and 150 µM, respectively). 产品目录编号 287897 品牌系列 Calbiochem®
同义词 3,3ʹ-Methylenebis(4-hydroxycoumarin), Bishydroxycoumarin, Dicumarol 参考 参考 Seanor, K.L., et al. 2003. Antioxid. Redox. Signal 5, 103.
Krause, D., et al. 2001. J. Biol. Chem. 276, 19244.
Pink, J.J., et al. 2000. J. Biol. Chem. 275, 5416.
Cross, J.V., et al. 1999. J. Biol. Chem. 274, 31150.
Morrow, C.S., et al. 1998. J. Biol. Chem. 273, 20114.
Weigert, R., et al. 1997. J. Biol. Chem. 272, 14200.产品信息 CAS号 66-76-2 具有ATP竞争性 N 形式 White solid Hill配方 C₁₉H₁₂O₆ 化学配方 C₁₉H₁₂O₆ Molar Mass 336.3 可逆 N 结构配方图像 生物信息 主靶 Blocks brefeldin A-dependent mono-ADP-ribosylation in vitro 主靶IC50 180 µM and 150 µM in blocking brefeldin A-dependent mono-ADP-ribosylation in vitro and Golgi disassembly in living cells, respectively 纯度 ≥98% by titration 理化信息 细胞可渗透 Y 溶解度 Aqueous alkaline solutions or organic bases GHS安全信息 RTECS GN7875000 安全信息 R相 R: 22-48/25-51/53
Harmful if swallowed.
Toxic: danger of serious damage to health by prolonged exposure if swallowed.
Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.S相 S: 37-45-61
Wear suitable gloves.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Avoid release to the environment. Refer to special instructions/safety data sheet.储存和货运信息 货运代码 Ambient Temperature Only
毒性 Toxic & Carcinogenic / Teratogenic
有害材料注意事项： Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Unstable in solution; reconstitute just prior to use. 包装信息 惰性气体下包装 Packaged under inert gas
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