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经验配方 CAS号 C₁₆H₁₀O₅ 477-84-9 描述 概述 A cell-permeable, potent, reversible, and selective inhibitor of p56lck tyrosine kinase. Inhibits p56lck autophosphorylation (IC50 = 17 nM) and phosphorylation of an exogenous peptide by p56lck (IC50 = 620 nM). Exhibits over 100-fold greater selectivity for p56lck over PKA and PKC, 40-fold greater selectivity for p56lck over EGF receptor kinase, c-ErbB2, insulin receptor kinase, and PDGF receptor kinase, and 7 - 20-fold greater selectivity for p56lck over p60src and p59fyn. Inhibition of p56lck is not significantly affected by the presence of sulfhydryl reagents. Also known to have antimalarial properties and to reverse the phenotype of ras-transformed cells. 产品目录编号 251650 品牌系列 Calbiochem®
同义词 3-Hydroxy-1-methoxyanthraquinone-2-aldehyde 参考 参考 Faltynek, C.R., et al. 1995. Biochemistry 34, 12404.
Hiramatsu, T., et al. 1993. Cancer Lett. 73, 161.
Koumaglo, K., et al. 1992. Planta Med. 58, 533.产品信息 CAS号 477-84-9 具有ATP竞争性 N 形式 Orange-yellow solid Hill配方 C₁₆H₁₀O₅ 化学配方 C₁₆H₁₀O₅ Molar Mass 282.3 可逆 Y 结构配方图像 生物信息 主靶 p56lck autophosphorylation 主靶IC50 17 nM against p56lck autophosphorylation 纯度 ≥95% by HPLC 理化信息 细胞可渗透 Y 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
上一件merck millipore产品：merck millipore,默克密理博,540200,PTP Inhibitor I - CAS 2491-38-5 - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,444232,MMP-9, Dimer, Human Neutrophil
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