merck millipore,默克密理博,250255,Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0

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merck millipore,默克密理博,250255,Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem
产品名称：Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem
产品型号：250255
Cell-permeable fungal toxin.

merck millipore,默克密理博,250255,Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

产品介绍

merck millipore,默克密理博,250255,Cytochalasin D, Zygosporium mansonii - CAS 22144-77-0 - Calbiochem

重要规格表

经验配方	CAS号
C₃₀H₃₇NO₆	22144-77-0

描述
概述	Cell-permeable fungal toxin. About 10-fold more potent than cytochalasin B in inhibiting actin filament function. Does not inhibit monosaccharide transport across cell membranes. Inhibits cytoplasmic division by blocking the formation of contractile microfilaments. Inactivates low conductance K⁺ channels. Also modulates CD4 cross-linking in T lymphocytes and increases intracellular Ca²⁺ levels. Exhibits antitumor activity. Also available as a 10 mM solution in DMSO (Cat. No. 504776).
产品目录编号	250255
品牌系列	Calbiochem®

参考
参考	Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026. Blankson, H., et al. 1995. Exp. Cell Res. 218, 522. Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102. Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335. Aszalos, A., et al. 1994. Cell Immunol. 157, 81. Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592. Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q. Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

参考

Sasaki, H., et al. 1995. Proc. Natl. Acad. Sci. USA 92, 2026.
Blankson, H., et al. 1995. Exp. Cell Res. 218, 522.
Melamed, I., et al. 1995. Biochem. Biophys. Res. Commun. 209, 1102.
Verschueren, H., et al. 1995. Eur. J. Cell Biol. 66, 335.
Aszalos, A., et al. 1994. Cell Immunol. 157, 81.
Wang, W.H., et al. 1994. Am. J. Physiol. 267, F592.
Betina, V., and Micekova, D. 1972. Chem. Abstr. 77, 160508q.
Katagiri, K., and Matsuura, S. 1971. J. Antibiot. 24, 722.

产品信息
CAS号	22144-77-0
具有ATP竞争性	N
形式	White solid
Hill配方	C₃₀H₃₇NO₆
化学配方	C₃₀H₃₇NO₆
Molar Mass	507.6
可逆	N
结构配方图像

生物信息
主靶	Actin filament function
纯度	≥98% by TLC

理化信息
细胞可渗透	Y
溶解度	DMSO or EtOH

GHS安全信息
RTECS	GZ4850000

安全信息
R相	R: 26/27/28-61 Very toxic by inhalation, in contact with skin and if swallowed. May cause harm to the unborn child.
S相	S: 3/7/9-22-36/37/39-45 Keep container tightly closed, in a cool well ventilated place. Do not breathe dust. Wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

储存和货运信息
货运代码	Ambient Temperature Only
毒性	Highly Toxic & Carcinogenic / Teratogenic
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	-20°C
避光	Protect from light
无需冷冻	No
特殊指南	Following reconstitution in chloroform, aliquot, dry under a stream of nitrogen, and freeze (-20°C). Reconstitute in DMSO just prior to use. Dried aliquots are stable for up to 3 months at -20°C.