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merck millipore,默克密理博,239821,CXCR4 Antagonist II - CAS 1258011-83-4 - Calbiochem
产品名称：CXCR4 Antagonist II - CAS 1258011-83-4 - Calbiochem
产品型号：239821
The CXCR4 Antagonist II, also referenced under CAS 1258011-83-4, controls the biological activity of CXCR4. This small molecule/inhibitor is primarily used for Cell Signaling applications.
merck millipore,默克密理博,239821,CXCR4 Antagonist II - CAS 1258011-83-4 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₁H₃₄N₄S₂ • HCl 1258011-83-4 描述 概述 A thiopseudourea compound that acts as a selective and highly potent CXCR4/Fusin antagonist (IC50 = 1.1 nM against SDF-1/CXCL12-induced Ca2+ mobilization in CEM cells) and effectively targets CXCR4-mediated binding of both CXCL12 (IC50 = 8 and 11 nM in competitive binding assays using human CEM and rat IR983F membrane, respectively) and HIV gp120 (IC50 = 7 nM in HIV attachment assays). Shown to be orally available in rat with good in vivo pharmacokinetics (32% availability, tmax = 0.5 h, Cmax= 18 ng/ml, t1/2 = 7.6 h, based on an oral dose of 1 mg/kg). Comparing to AMD3100 (Cat. No. 239820), CXCR4 Antagonist II is ~30-times more potent as a CXCR4-CXCL12 interaction blocker, while being ~2-fold less potent in blocking gp120-mediated HIV attachment. 产品目录编号 239821 品牌系列 Calbiochem®
同义词 1,3-Dicyclohexyl-2-(3-methyl-6,6-dimethyl-5,6-dihydroimidazo[1,2-b]thiazole)-2-thiopseudourea, HCl, Fusin Antagonist II, IT1t 参考 参考 Wu, B., et al. 2010. Science 330, 1066.
Thoma, G., et al. 2008. J. Med. Chem. 51, 7915.产品信息 CAS号 1258011-83-4 形式 White solid Hill配方 C₂₁H₃₄N₄S₂ • HCl 化学配方 C₂₁H₃₄N₄S₂ • HCl Molar Mass 443.1 吸湿 Hygroscopic
结构配方图像 生物信息 纯度 ≥95% by HPLC 理化信息 溶解度 DMSO 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 -20°C
避光 Protect from light
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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