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经验配方 C₄₄H₆₃N₃O₄ 描述 概述 A potent, cell-permeable analog of Cyclopamine (Cat. No. 239803) that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20 nM in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Also available as a 1 mM solution in DMSO (Cat. No. 239807). 产品目录编号 239804 品牌系列 Calbiochem®
同义词 3-Keto-N-(aminoethyl-aminocaproyl-dihydrocinnamoyl)cyclopamine, KAAD-Cyclopamine, Shh Signaling Antagonist II 参考 参考 Siegelin, M.D. et al. 2009. Neurobiol. Dis. 34, 259.
Watkins, D.N., et al. 2003. Nature 422, 313.
Berman, D.M., et al. 2002. Science 297, 1559.
Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
Chen, J.K., et al. 2002. Genes Dev. 16, 2743.
Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
Taipale, J., et al. 2000. Nature 406, 1005.产品信息 具有ATP竞争性 N 形式 Pale yellow solid Hill配方 C₄₄H₆₃N₃O₄ 化学配方 C₄₄H₆₃N₃O₄ Molar Mass 698.0 可逆 N 结构配方图像 生物信息 主靶 Hh signaling in Shh-light2 assay 主靶IC50 20 nM against Hedgehog (Hh) signaling in Shh-LIGHT2 assay; 50 nM in p2Ptch-/-cells; 500 nM in SmoA1-LIGHT cells 纯度 ≥70% by HPLC (sum of two isomers) 理化信息 细胞可渗透 Y 溶解度 DMSO, EtOH, or MeOH 安全信息 R相 R: 20/21/22
Harmful by inhalation, in contact with skin and if swallowed.S相 S: 22-36/37
Do not breathe dust.
Wear suitable protective clothing and gloves.储存和货运信息 货运代码 Shipped with Blue Ice or with Dry Ice
毒性 Harmful
储存 -20°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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