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主要应用 品种 级联部件 EA Human Substrate 描述 产品目录编号 23-043M 品牌系列 Upstate
商名 - Upstate
描述 Kit Protein, 250 µg 长描述 N-terminal c-Myc, GST-tagged, recombinant human Kit amino acids 544-end, expressed by baculovirus in Sf21 insect cells. Purified using glutathione sepharose. Alternate Names - CD_antigen=CD117
- Mast/stem cell growth factor receptor
- Proto-oncogene c-Kit
- Tyrosine-protein kinase Kit
背景信息 Kit belongs to the family of type III receptor tyrosine kinases. It mediates the cellular response to stem cell factor and plays a major role in survival, expansion and differentiation of haematopoietic progenitor cells and reproductive stem cells. The activation of Kit is tightly regulated and uncontrolled Kit activity contributes to the growth of diverse human tumours. Gain-of-function mutations have been described in a number of malignancies, including acute myeloid leukaemia, small cell lung cancer, gastrointestinal stromal tumours and testicular cancer. Negative regulation of Kit signalling has been shown to occur mainly through ubiquitin-mediated internalization and degradation of the receptor. 应用 应用 Recombinant human Kit, amino acids 544-end. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays. 主要应用 - Enzyme Assay
生物信息 品种 Human 特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme. 级联部件 Substrate Entrez基因编号 - X06182 (GenBank Number)
纯化方法 Purified using glutathione sepharose. 产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
包装信息 数量 250 µg
上一件merck millipore产品：merck millipore,默克密理博,HTS020M2,ChemiSCREEN™ Membrane Preparation Recombinant Human CB2 Canabinoid Receptor Optimized for GTPγS Assay
下一件merck millipore产品：merck millipore,默克密理博,AB12226,Anti-RALY Antibody
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